Department of Applied Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan; Global R&D, Menicon Co., Ltd., Nagoya, Japan.
Department of Innovative Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan; Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.
Cont Lens Anterior Eye. 2021 Aug;44(4):101405. doi: 10.1016/j.clae.2020.12.071. Epub 2021 Jan 10.
To report on a second-generation prototype contact lens (modified lens) with enhanced optics to correct coma aberration and compare its performance with that of the prototype contact lens (conventional lens) used to optimise correction of coma aberration in keratoconus (KC).
Both lenses were designed as a set of standardised soft contact lenses (SCLs) with asymmetric powers along the posterior surface. The modified lens differs from the conventional lens in that the optical zone is decentred superiorly by 0.7 mm. The on-eye performance was compared between the SCLs and no-lens wearing in terms of manifest refraction, corrected distance visual acuity (CDVA), ocular aberrations, subjective quality of vision, and on-eye lens position relative to the pupil.
Thirty-four KC eyes were included. SCLs significantly decreased coma aberration compared to no-lens wear (none, 0.68 ± 0.27 μm; conventional lens, 0.37 ± 0.28 μm; modified lens, 0.19 ± 0.15 μm; P < 0.001), with the reduction in coma aberration being significantly greater with the modified lens than with the conventional lens (P = 0.018). No significant difference in manifest refraction or CDVA was found among the three conditions. Quality of vision was significantly better with the modified lens than with no SCL wear (P < 0.05) but no differences were found between the SCLs. The on-eye optical center position relative to the pupil was closer to the pupil centre using the modified lens than the conventional lens (P < 0.001).
Optimisation of the location of the optical zone in a standardised asymmetric SCL improves correction of coma aberrations and on-eye optical centration.
报告一种具有增强光学性能的第二代原型接触镜（改良镜），并比较其性能与用于优化圆锥角膜（KC） coma 像差校正的原型接触镜（常规镜）的性能。
两种镜片均设计为具有不对称后表面的一组标准化软性隐形眼镜（SCL）。改良镜与常规镜的区别在于光学区在上部偏心 0.7 毫米。在无镜片佩戴的情况下，通过对比角膜像差、矫正远距视力（CDVA）、眼像差、主观视觉质量以及镜片相对于瞳孔的佩戴位置，比较 SCL 与无镜片佩戴的眼上性能。
纳入 34 只 KC 眼。与无镜片佩戴相比，SCL 显著降低了 coma 像差（无镜片，0.68±0.27μm；常规镜，0.37±0.28μm；改良镜，0.19±0.15μm；P＜0.001），改良镜的 coma 像差降低幅度明显大于常规镜（P=0.018）。三种情况下的屈光度和 CDVA 无显著差异。与无 SCL 佩戴相比，改良镜的视觉质量明显更好（P＜0.05），但 SCL 之间无差异。与常规镜相比，改良镜的眼上光学中心位置更接近瞳孔中心（P＜0.001）。
在标准化的不对称 SCL 中优化光学区的位置可改善 coma 像差的校正和眼上光学中心定位。
