新型冠状病毒肺炎危重症患者高血糖的重要性：机制与治疗策略。
Importance of hyperglycemia in COVID-19 intensive-care patients: Mechanism and treatment strategy.
机构信息
Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; Department of Anatomical Sciences, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Clinical Biochemistry, Hamadan University of Medical Sciences, Hamadan, Iran.
出版信息
Prim Care Diabetes. 2021 Jun;15(3):409-416. doi: 10.1016/j.pcd.2021.01.002. Epub 2021 Jan 9.
This review reported that coronavirus disease 2019 (COVID-19) infected patients with short time bed rest or quarantine and airway inflammation are at more risk of developing hyperglycemia and insulin resistance. This condition can induce oxidative stress, decrease immune system function, impair endothelial function, induce apoptosis, and reduce antioxidant in the lungs. We provide a possible mechanism in severe COVID-19 patients and recommend treatment strategy to reduce mortality rate and prevent adverse outcomes after intensive care unit (ICU).
这篇综述报道称，感染 2019 冠状病毒病（COVID-19）的患者在短时间卧床休息或隔离期间以及气道炎症时，更易发生高血糖和胰岛素抵抗。这种情况会导致氧化应激，降低免疫系统功能，损害内皮功能，诱导细胞凋亡，并减少肺部的抗氧化剂。我们提供了严重 COVID-19 患者的一种可能机制，并建议了治疗策略，以降低重症监护病房（ICU）后的死亡率和预防不良后果。
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