School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.
National Key Laboratory of Human Factors Engineering, China Astronaut Research and Training Center, Beijing, 100094, China.
Sci Rep. 2021 Jan 12;11(1):484. doi: 10.1038/s41598-020-79816-8.
Cognitive abilities are impaired by sleep deprivation and can be recovered when sufficient sleep is obtained. Changes in alpha-band oscillations are considered to be closely related to sleep deprivation. In this study, power spectrum, source localization and functional connectivity analyses were used to investigate the changes in resting-state alpha-band activity after normal sleep, sleep deprivation and recovery sleep. The results showed that the global alpha power spectrum decreased and source activation was notably reduced in the precuneus, posterior cingulate cortex, cingulate gyrus, and paracentral lobule after sleep deprivation. Functional connectivity analysis after sleep deprivation showed a weakened functional connectivity pattern in a widespread network with the precuneus and posterior cingulate cortex as the key nodes. Furthermore, the changes caused by sleep deprivation were reversed to a certain extent but not significantly after one night of sleep recovery, which may be due to inadequate time for recovery sleep. In conclusion, large-scale resting-state alpha-band activation and functional connectivity were weakened after sleep deprivation, and the inhibition of default mode network function with the precuneus and posterior cingulate cortex as the pivotal nodes may be an important cause of cognitive impairment. These findings provide new insight into the physiological response to sleep deprivation and determine how sleep deprivation disrupts brain alpha-band oscillations.
认知能力会因睡眠剥夺而受损，而当获得充足的睡眠时，这些能力可以得到恢复。alpha 波段振荡的变化被认为与睡眠剥夺密切相关。在这项研究中，使用功率谱、源定位和功能连接分析来研究正常睡眠、睡眠剥夺和恢复性睡眠后静息状态 alpha 波段活动的变化。结果表明，睡眠剥夺后，全局 alpha 功率谱降低，楔前叶、后扣带回皮质、扣带回和旁中央小叶的源激活明显减少。睡眠剥夺后的功能连接分析显示，以楔前叶和后扣带回皮质为关键节点的广泛网络中的功能连接模式减弱。此外，一夜恢复性睡眠后，睡眠剥夺引起的变化在一定程度上得到了逆转，但并不显著，这可能是由于恢复性睡眠的时间不足。总之，睡眠剥夺后，大范围静息状态 alpha 波段激活和功能连接减弱，以楔前叶和后扣带回皮质为关键节点的默认模式网络功能抑制可能是认知障碍的重要原因。这些发现为睡眠剥夺的生理反应提供了新的见解，并确定了睡眠剥夺如何破坏大脑 alpha 波段振荡。
