Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Universitario Puerta del Mar, Facultad de Medicina, Universidad de Cádiz, Cádiz, Spain. Instituto de Investigación e Innovación en Ciencias Biomédicas de la Provincia de Cádiz (INiBICA).
Int J Med Sci. 2021 Jan 1;18(3):846-851. doi: 10.7150/ijms.50133. eCollection 2021.
In the last 50 years we have experienced two big pandemics, the HIV pandemic and the pandemic caused by SARS-CoV-2. Both pandemics are caused by RNA viruses and have reached us from animals. These two viruses are different in the transmission mode and in the symptoms they generate. However, they have important similarities: the fear in the population, increase in proinflammatory cytokines that generate intestinal microbiota modifications or NETosis production by polymorphonuclear neutrophils, among others. They have been implicated in the clinical, prognostic and therapeutic attitudes.
在过去的 50 年中,我们经历了两次大的传染病疫情,一次是由 HIV 引起的,另一次是由 SARS-CoV-2 引起的。这两种传染病疫情都是由 RNA 病毒引起的,并且都来自于动物。这两种病毒在传播方式和引起的症状上有所不同。然而,它们有一些重要的相似之处:例如,它们在人群中引起的恐惧、促炎细胞因子的增加,导致肠道微生物群的改变或多形核中性粒细胞产生 NETosis。这些都与临床、预后和治疗态度有关。