Qi Yajun, Ying Yin, Zou Jie, Fang Qilu, Yuan Xiaohong, Cao Yingying, Cai Yunfang, Fu Shuang
Department of Pharmacy, The Cancer Hospital of The University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences Hangzhou 310022, Zhejiang, China.
Department of Pharmacy, Tongde Hospital of Zhejiang Province Hangzhou 310012, Zhejiang, China.
Am J Transl Res. 2020 Dec 15;12(12):8007-8018. eCollection 2020.
Cardiovascular complications have been well documented as the downside to conventional cancer chemotherapy. As a notable side effect of cisplatin, cardiotoxicity represents a major obstacle to the successful treatment of cancer. It has been reported that kaempferol (KPF) possesses cardioprotective and anti-inflammatory qualities. However, the effect of KPF on cardiac damage caused by conventional cancer chemotherapy remains unclear. In this study, we clarified the protective effect of KPF on cisplatin-induced heart injury, and conducted in-depth research on the molecular mechanism underlying this effect. The results showed that KPF protected against cardiac dysfunction and injury induced by cisplatin . In H9c2 cells, KPF dramatically reduced cispaltin-induced apoptosis and inflammatory response by modulating STING/NF-κB pathway. In conclusion, these results showed that KPF had great potential in attenuating cisplatin-induced cardiac injury. Besides, greater emphasis should be placed in the future on natural active compounds containing KPF with anti-inflammatory effects for the treatment of these diseases.
心血管并发症已被充分证明是传统癌症化疗的不利之处。作为顺铂的一种显著副作用，心脏毒性是癌症成功治疗的一个主要障碍。据报道，山奈酚（KPF）具有心脏保护和抗炎特性。然而，KPF对传统癌症化疗引起的心脏损伤的影响仍不清楚。在本研究中，我们阐明了KPF对顺铂诱导的心脏损伤的保护作用，并对其作用的分子机制进行了深入研究。结果表明，KPF可预防顺铂诱导的心脏功能障碍和损伤。在H9c2细胞中，KPF通过调节STING/NF-κB通路显著减少顺铂诱导的细胞凋亡和炎症反应。总之，这些结果表明KPF在减轻顺铂诱导的心脏损伤方面具有巨大潜力。此外，未来应更加重视含有KPF的具有抗炎作用的天然活性化合物用于治疗这些疾病。
