Upasham Sayali, Bhide Ashlesha, Lin Kai-Chun, Prasad Shalini
Department of Bioengineering, University of Texas at Dallas, Richardson, TX 75080, USA.
Future Sci OA. 2020 Oct 22;7(1):FSO628. doi: 10.2144/fsoa-2020-0097.
The hypothalamic-pituitary-adrenal axis is involved in maintaining homeostasis by engaging with the parasympathetic nervous system. During the process of disease affliction, this relationship is disturbed and there is an imbalance driven response observed.
MATERIALS & METHODS: By monitoring the two key components involved in these pathways, cortisol and TNF-α, the manifestations of chronic stress on the body's homeostasis can be evaluated in a comprehensive manner. This work highlights the development of an electrochemical detection system for the two biomarkers through human sweat.
Limit of detection and dynamic ranges are 1 ng/ml, 1-200 ng/ml for cortisol and 1 pg/ml, 1-1000 pg/ml for TNF-α.
This wearable system is designed to be a point of use, chronic disease self-monitoring and management platform.
下丘脑-垂体-肾上腺轴通过与副交感神经系统相互作用参与维持体内平衡。在疾病折磨过程中，这种关系受到干扰，观察到一种失衡驱动的反应。
通过监测这些途径中涉及的两个关键成分，即皮质醇和肿瘤坏死因子-α，可以全面评估慢性应激对身体内稳态的影响。这项工作重点介绍了一种通过人体汗液对这两种生物标志物进行电化学检测系统的开发。
皮质醇的检测限和动态范围分别为1 ng/ml、1 - 200 ng/ml，肿瘤坏死因子-α的检测限和动态范围分别为1 pg/ml、1 - 1000 pg/ml。
这种可穿戴系统旨在成为一个即时使用的慢性病自我监测和管理平台。
