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Shedding Light on Extracellular Vesicle Biogenesis and Bioengineering.

作者信息

Teng Fei, Fussenegger Martin

机构信息

Department of Biosystems Science and Engineering ETH Zurich Mattenstrasse 26 Basel CH-4058 Switzerland.

Faculty of Science University of Basel Mattenstrasse 26 Basel CH-4058 Switzerland.

出版信息

Adv Sci (Weinh). 2020 Nov 27;8(1):2003505. doi: 10.1002/advs.202003505. eCollection 2020 Jan.

DOI:10.1002/advs.202003505
PMID:33437589
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7788585/
Abstract

Extracellular vesicles (EVs) are biocompatible, nano-sized secreted vesicles containing many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their low immunogenicity and ability to functionally modify recipient cells by transferring diverse bioactive constituents make them an excellent candidate for a next-generation drug delivery system. Here, the recent advances in EV biology and emerging strategies of EV bioengineering are summarized, and the prospects for clinical translation of bioengineered EVs and the challenges to be overcome are discussed.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a39/7788585/bdae589d23ed/ADVS-8-2003505-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a39/7788585/1d0dfa3986cd/ADVS-8-2003505-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a39/7788585/7610ea26ee63/ADVS-8-2003505-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a39/7788585/c9d03ef0cf88/ADVS-8-2003505-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a39/7788585/37a96477ac77/ADVS-8-2003505-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a39/7788585/bdae589d23ed/ADVS-8-2003505-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a39/7788585/1d0dfa3986cd/ADVS-8-2003505-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a39/7788585/7610ea26ee63/ADVS-8-2003505-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a39/7788585/c9d03ef0cf88/ADVS-8-2003505-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a39/7788585/37a96477ac77/ADVS-8-2003505-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a39/7788585/bdae589d23ed/ADVS-8-2003505-g005.jpg

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Shedding Light on Extracellular Vesicle Biogenesis and Bioengineering.

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本文引用的文献

[1]
An exosome pathway without an ESCRT.

Cell Res. 2021-2

[2]
The evolving translational potential of small extracellular vesicles in cancer.

Nat Rev Cancer. 2020-12

[3]
RAB31 marks and controls an ESCRT-independent exosome pathway.

Cell Res. 2021-2

[4]
RNA delivery by extracellular vesicles in mammalian cells and its applications.

Nat Rev Mol Cell Biol. 2020-5-26

[5]
Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes.

ACS Nano. 2020-4-28

[6]
Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR-Cas gene editing.

Nat Nanotechnol. 2020-4-6

[7]
Tetraspanin-6 negatively regulates exosome production.

Proc Natl Acad Sci U S A. 2020-2-27

[8]
ALIX- and ESCRT-III-dependent sorting of tetraspanins to exosomes.

J Cell Biol. 2020-3-2

[9]
The biology function and biomedical applications of exosomes.

Science. 2020-2-7

[10]
Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis.

Nat Nanotechnol. 2020-1-27

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