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M提取物可改善对苯二胺诱导的角质形成细胞毒性。

M. extract ameliorate -phenylenediamine-induced toxicity in keratinocytes.

作者信息

Woo Hyunju, Kim Hayeon, Shin Seoungwoo, Shin Jong Heon, Ryu Dehun, Park Deokhoon, Jung Eunsun

机构信息

BioSpectrum Life Science Institute, U-TOWER 18th FL, 767, Sinsu-Ro, Suji-Gu, Yongin-Si, Gyeonggi-Do, 16827, Republic of Korea.

出版信息

Toxicol Rep. 2020 Dec 26;8:96-105. doi: 10.1016/j.toxrep.2020.12.020. eCollection 2021.

DOI:10.1016/j.toxrep.2020.12.020
PMID:33437652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7786012/
Abstract

-Phenylediamine (PPD), a major component of hair dyeing ingredients, can induce allergenic sensitization and exert mutagenic, tumorigenic and cytotoxic effect. In this study, we determined the cytotoxic effect of PPD on human keratinocytes and evaluated the protective effect of M. extracts (RSE) on PPD induced cytotoxicity for the first time. We observed that RSE is a strong inhibitory agent against PPD-induced toxicity in human keratinocytes. The results indicated that RSE pretreatment significantly could suppress PPD induced cytotoxic effects, including decrease of cell viability, accumulation in subG1 phase of cells, and relocation of phosphatidylserine on keratinocytes. Also, we found that PPD caused cytotoxicity was associated with mitochondrial membrane potential loss and subsequent activation of caspase and PARP degradation. However, pretreatment of RSE showed preventive activities against PPD induced mitochondrial membrane potential loss and ROS production in keratinocytes. In conclusion, the results of present study suggest that RSE was able to protect the skin from several cytotoxic effects of PPD and could be a meaningful material in many industries using PPD.

摘要

对苯二胺（PPD）是染发剂成分的主要组成部分，可引发过敏致敏反应，并具有诱变、致癌和细胞毒性作用。在本研究中，我们首次测定了PPD对人角质形成细胞的细胞毒性，并评估了迷迭香叶提取物（RSE）对PPD诱导的细胞毒性的保护作用。我们观察到RSE是一种针对PPD诱导的人角质形成细胞毒性的强效抑制剂。结果表明，RSE预处理可显著抑制PPD诱导的细胞毒性作用，包括细胞活力降低、细胞在亚G1期的积累以及角质形成细胞上磷脂酰丝氨酸的重新分布。此外，我们发现PPD引起的细胞毒性与线粒体膜电位丧失以及随后的半胱天冬酶激活和PARP降解有关。然而，RSE预处理显示出对PPD诱导的角质形成细胞线粒体膜电位丧失和活性氧产生的预防作用。总之，本研究结果表明，RSE能够保护皮肤免受PPD的多种细胞毒性作用，并且在许多使用PPD的行业中可能是一种有意义的材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec3/7786012/2a51319fff22/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec3/7786012/db08b53396eb/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec3/7786012/4c2c40963523/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec3/7786012/c9ffb487815e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec3/7786012/ad9a37d58324/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec3/7786012/9a7c6e9c7993/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec3/7786012/79fa608ef650/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec3/7786012/2a51319fff22/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec3/7786012/db08b53396eb/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec3/7786012/4c2c40963523/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec3/7786012/c9ffb487815e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec3/7786012/ad9a37d58324/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec3/7786012/9a7c6e9c7993/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec3/7786012/79fa608ef650/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec3/7786012/2a51319fff22/gr6.jpg

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