Department of Orthopaedics and Trauma, Afe Babalola University Multi-System Hospital, Ado-Ekiti, Ekiti State, Nigeria.
Accidents and Emergency Unit, ABUAD Multi-System Hospital, Ado-Ekiti, Ekiti State, Nigeria.
Int Orthop. 2021 Mar;45(3):551-557. doi: 10.1007/s00264-021-04943-4. Epub 2021 Jan 12.
Current modes of diagnosing and monitoring knee osteoarthritis (OA) are based on weight bearing radiographs usually made by the time joint destruction is already established. Cartilage oligomeric matrix protein (COMP) is a breakdown product of cartilage and its serum levels may be a potential indicator of early destruction in OA. This study aimed to ascertain the usefulness of serum COMP (sCOMP) in diagnosis and monitoring of knee joint OA within the study environment.
Ninety consenting adults were recruited. In the control group, 45 subjects having a diagnosis of knee OA had clinical and radiological grading done and blood samples taken for assay of sCOMP using the sandwich ELISA method. Forty-five volunteers with no features of osteoarthritis also had serum collected for sCOMP assay. Values obtained were then cross referenced with demographic indices, clinical and radiological severity grade to assess for relationships.
Serum COMP was found to be significantly elevated (p = 0.0001) in the study group. The mean values and standard deviation of sCOMP were 3400 ± 1042.9 ng/ml and 2222 ± 605.6 ng/ml for the study and control groups, respectively. Higher values of sCOMP were found to be associated with higher clinical and radiological grades of OA.
The study demonstrates that sCOMP is significantly higher in patients with knee OA than in those without the disease. Values of sCOMP were also found to increase with severity of knee OA, indicating the possibility of its use as a marker of diagnosis and severity.
目前诊断和监测膝骨关节炎（OA）的模式基于负重 X 射线，通常在关节破坏已经确立时进行。软骨寡聚基质蛋白（COMP）是软骨的降解产物，其血清水平可能是 OA 早期破坏的潜在指标。本研究旨在确定血清 COMP（sCOMP）在研究环境中诊断和监测膝关节 OA 的有用性。
招募了 90 名同意的成年人。在对照组中，45 名诊断为膝 OA 的患者进行了临床和放射学分级，并采集血液样本用于夹心 ELISA 法测定 sCOMP。45 名无骨关节炎特征的志愿者也采集了血清用于 sCOMP 测定。然后将获得的值与人口统计学指标、临床和放射学严重程度等级进行交叉参考，以评估相关性。
研究组血清 COMP 明显升高（p = 0.0001）。sCOMP 的平均值和标准差分别为研究组 3400 ± 1042.9 ng/ml 和对照组 2222 ± 605.6 ng/ml。发现较高的 sCOMP 值与 OA 的较高临床和放射学等级相关。
该研究表明，膝 OA 患者的 sCOMP 明显高于无该疾病的患者。sCOMP 的值也随着膝 OA 的严重程度增加而增加，表明其作为诊断和严重程度标志物的可能性。
