Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands.
Biochem Soc Trans. 2021 Feb 26;49(1):203-215. doi: 10.1042/BST20200425.
Natural peptide products are a valuable source of important therapeutic agents, including antibiotics, antivirals and crop protection agents. Aided by an increased understanding of structure-activity relationships of these complex molecules and the biosynthetic machineries that produce them, it has become possible to re-engineer complete machineries and biosynthetic pathways to create novel products with improved pharmacological properties or modified structures to combat antimicrobial resistance. In this review, we will address the progress that has been made using non-ribosomally produced peptides and ribosomally synthesized and post-translationally modified peptides as scaffolds for designed biosynthetic pathways or combinatorial synthesis for the creation of novel peptide antimicrobials.
天然肽产物是重要治疗剂的宝贵来源，包括抗生素、抗病毒药物和作物保护剂。由于对这些复杂分子的结构-活性关系以及产生它们的生物合成机制有了更深入的了解，现在已经有可能对完整的生物合成机制和途径进行重新设计，以创造具有改善的药理学性质或修饰结构的新型产品，以对抗抗菌药物耐药性。在这篇综述中，我们将讨论利用非核糖体产生的肽和核糖体合成及翻译后修饰的肽作为设计生物合成途径或组合合成新型肽抗生素的支架所取得的进展。
