核糖体合成和翻译后修饰肽天然产物生物合成逻辑的新见解。
New Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products.
机构信息
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Department of Chemistry, Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
出版信息
Cell Chem Biol. 2016 Jan 21;23(1):31-44. doi: 10.1016/j.chembiol.2015.11.012.
Abstract
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large group of structurally diverse natural products. Their biological activities and unique biosynthetic pathways have sparked a growing interest in RiPPs. Furthermore, the relatively low genetic complexity associated with RiPP biosynthesis makes them excellent candidates for synthetic biology applications. This Review highlights recent developments in the understanding of the biosynthesis of several bacterial RiPP family members, the use of the RiPP biosynthetic machinery for generating novel macrocyclic peptides, and the implementation of tools designed to guide the discovery and characterization of novel RiPPs.
摘要
核糖体合成和翻译后修饰肽（RiPPs）是一大类结构多样的天然产物。它们的生物活性和独特的生物合成途径引起了人们对 RiPPs 的日益关注。此外，与 RiPP 生物合成相关的遗传复杂性相对较低，这使得它们成为合成生物学应用的优秀候选者。本文综述了近年来对几种细菌 RiPP 家族成员生物合成的理解、利用 RiPP 生物合成机制生成新型大环肽，以及实施旨在指导新型 RiPP 发现和表征的工具方面的最新进展。
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