Controlled Drug Delivery Systems and Biomaterials, University of Lille, Inserm, Lille, France.
LIRIC - Lille Inflammation Research International Center, University of Lille, Inserm, Lille, France.
Am J Dent. 2020 Dec;33(6):305-309.
To evaluate an injectable gel, recently proposed for the controlled release of "active oxygen" in periodontal pockets, compared to an antibiotic or an antiseptic gel, respectively.
The antimicrobial activity, injectability, texture properties, swelling and water uptake of the gels were studied.
The "active oxygen" gel showed a bactericidal effect comparable to the two commercially available drug products (containing minocycline or chlorhexidine) on anaerobic periodontal pathogens and did not seem to affect aerobic strains. The gel was easy to inject and stable in an aqueous medium for several days. Texture analysis revealed potential gel fragility.
The investigated gel for local delivery of oxygen can help to selectively eradicate anaerobic bacteria associated with periodontitis and promote the recovery of a healthy-compatible oral flora.
评估一种最近提出的用于牙周袋内“活性氧”控制释放的可注射凝胶，分别与抗生素或抗菌凝胶进行比较。
研究了凝胶的抗菌活性、可注射性、质地特性、溶胀和吸水率。
“活性氧”凝胶对厌氧牙周病原体具有与两种市售药物产品（含米诺环素或洗必泰）相当的杀菌作用，并且似乎不影响需氧菌株。该凝胶易于注射，在水性介质中稳定数天。质地分析显示潜在的凝胶脆性。
用于局部输送氧气的研究凝胶有助于选择性根除与牙周炎相关的厌氧菌，并促进健康相容的口腔菌群的恢复。
