Killoy W J
Int Dent J. 1998 Jun;48(3 Suppl 1):305-15. doi: 10.1111/j.1875-595x.1998.tb00721.x.
Periodontitis is a bacterial infection. It appears in a generalised form but more often appears in local areas in a patient's mouth or is reduced to localised areas by mechanical treatment. Periodontitis lends itself well to treatment by means of a controlled local delivery system using an antimicrobial agent. Several products have been introduced or are in the process of clearing regulatory agencies. It is the goal of all local delivery systems to deliver high concentrations of an antimicrobial directly to the site of the periodontal infection. Concentrations of medication can be achieved considerably higher than could be obtained with systemic administration, while the systemic uptake of the medication is minimal. Five local delivery systems (tetracycline fibre, doxycycline polymer, chlorhexidine chip, minocycline ointment and metronidazole gel) are now available. Techniques for their use and the supporting scientific evidence are presented and indications for the use of the various systems are also discussed. These local delivery systems offer the clinician additional therapeutic procedures to aid in the treatment of the chronic inflammatory periodontal diseases.
牙周炎是一种细菌感染性疾病。它通常以全身性形式出现，但更常见的是出现在患者口腔的局部区域，或者通过机械治疗局限于局部区域。牙周炎很适合采用使用抗菌剂的可控局部给药系统进行治疗。已有几种产品推出或正处于通过监管机构审批的过程中。所有局部给药系统的目标都是将高浓度的抗菌剂直接输送到牙周感染部位。药物浓度可比全身给药时高得多，而药物的全身吸收量却极少。目前有五种局部给药系统（四环素纤维、强力霉素聚合物、洗必泰芯片、米诺环素软膏和甲硝唑凝胶）可供使用。本文介绍了它们的使用技术和相关科学证据，并讨论了各种系统的使用指征。这些局部给药系统为临床医生提供了额外的治疗手段，有助于治疗慢性炎症性牙周疾病。
