Institute of Medicine and Materials Applied Technologies, College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, Shandong 273165, P. R. China.
Org Lett. 2021 Feb 5;23(3):1081-1085. doi: 10.1021/acs.orglett.0c04296. Epub 2021 Jan 13.
The construction of functional N-containing active biomolecules and bidentate nitrogen ligands by electroreductive pyridylation of N-heteroaromatics is an eye-catching task and challenge. A simple and practical electroreductive-induced C3 pyridylation of quinoxalin-2(1)-ones with readily available cyanopyridines is reported. More than 36 examples are supplied, and the reaction performed in >95% yield. The present protocol provides a convenient, efficient, and gram-scale synthesis strategy for a series of new types of potential bidentate nitrogen ligands.
通过电化学还原杂芳环的吡啶化来构建功能 N 含有活性生物分子和双齿氮配体是一项引人注目的任务和挑战。本文报道了一种简单实用的电化学诱导喹喔啉-2(1)-酮与易得的氰基吡啶的 C3 吡啶化反应。提供了超过 36 个实例，反应收率大于 95%。本方案为一系列新型潜在双齿氮配体提供了一种方便、高效、克级规模的合成策略。
