Peters Eva Milena Johanne, Schedlowski Manfred, Watzl Carsten, Gimsa Ulrike
Klinik für Psychosomatik und Psychotherapie, Psychoneuroimmunologie Labor, Justus-Liebig Universität Gießen, Deutschland.
Medizinische Klinik mit Schwerpunkt Psychosomatik und Psychotherapie, CharitéCentrum 12 (CC12) für Innere Medizin und Dermatologie, Berlin, Deutschland.
Psychother Psychosom Med Psychol. 2021 Feb;71(2):61-71. doi: 10.1055/a-1322-3205. Epub 2021 Jan 13.
The COVID-19 pandemic is on the rise and causes many concerns and fears in the population as well as among medical care givers. This raises the question as to how psychosocial stress associated with the pandemic can be managed, and also if certain forms of stress can contribute to an increase in infections and critical illnesses.
Against the background of the current state of research on stress and the immune response, we provide a narrative review of studies addressing the question as to how stress can influence the immune defence against viral diseases.
Excessive stress can compromise the barrier function of the airways and alter neuroendocrine control of immune function, which can create a virus-permissive immune response.
Because certain forms of stress can play a role in the successful immune defence against viral respiratory disease, it is important to identify people with high psychosocial stress and to help them manage their stress. Conclusion Psychosocial measures that contribute to improved stress management may have a positive effect on the immune response against viral respiratory infections.
新冠疫情正在加剧，在普通民众以及医护人员中引发了诸多担忧和恐惧。这就引发了一个问题，即如何应对与疫情相关的心理社会压力，以及某些形式的压力是否会导致感染和重症病例增加。
基于当前关于压力与免疫反应的研究现状，我们对探讨压力如何影响针对病毒性疾病的免疫防御这一问题的研究进行了叙述性综述。
过度压力会损害气道的屏障功能，并改变免疫功能的神经内分泌控制，从而产生有利于病毒的免疫反应。
由于某些形式的压力可能在针对病毒性呼吸道疾病的成功免疫防御中发挥作用，识别出心理社会压力大的人群并帮助他们管理压力很重要。结论有助于改善压力管理的心理社会措施可能对针对病毒性呼吸道感染的免疫反应产生积极影响。
