MOVE-IT Research Group, Department of Physical Education, Faculty of Education Sciences, Universidad de Cádiz, 11519 Cadiz, Spain.
Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital, University of Cádiz, 11009 Cadiz, Spain.
Nutrients. 2021 Dec 22;14(1):24. doi: 10.3390/nu14010024.
Growing evidence supports the importance of lifestyle and environmental exposures-collectively referred to as the 'exposome'-for ensuring immune health. In this narrative review, we summarize and discuss the effects of the different exposome components (physical activity, body weight management, diet, sun exposure, stress, sleep and circadian rhythms, pollution, smoking, and gut microbiome) on immune function and inflammation, particularly in the context of the current coronavirus disease 2019 (COVID-19) pandemic. We highlight the potential role of 'exposome improvements' in the prevention-or amelioration, once established-of this disease as well as their effect on the response to vaccination. In light of the existing evidence, the promotion of a healthy exposome should be a cornerstone in the prevention and management of the COVID-19 pandemic and other eventual pandemics.
越来越多的证据支持生活方式和环境暴露（统称为“暴露组学”）对于确保免疫健康的重要性。在这篇叙述性综述中，我们总结和讨论了不同暴露组学成分（体力活动、体重管理、饮食、阳光暴露、压力、睡眠和昼夜节律、污染、吸烟和肠道微生物组）对免疫功能和炎症的影响，特别是在当前 2019 年冠状病毒病（COVID-19）大流行的背景下。我们强调了“暴露组学改善”在预防或减轻这种疾病（一旦确立）以及对疫苗接种反应的影响方面的潜在作用。鉴于现有证据，促进健康的暴露组学应该成为预防和管理 COVID-19 大流行及其他未来大流行的基石。
