Zhang Jin, Liu He, Ding Jian-Xun, Wu Jie, Zhuang Xiu-Li, Chen Xue-Si, Wang Jin-Cheng, Yin Jing-Bo, Li Zhong-Ming
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, Sichuan, P. R. China.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.
ACS Biomater Sci Eng. 2016 Sep 12;2(9):1471-1482. doi: 10.1021/acsbiomaterials.6b00202. Epub 2016 Aug 10.
Fabricating porous scaffolds with sufficient mechanical properties is a challenge for healing bone defects. High-pressure compression-molded (HPCM) porous composite scaffold comprising poly(l-lactide) (PLLA), poly(lactide--glycolide) (PLGA), and hydroxyapatite (HA) was prepared and showed upregulated mechanical properties due to a solid network structure and a highly ordered crystalline architecture. The compressive yield strength and modulus of the HPCM scaffold molded at 1000 MPa and 180 °C were 0.91 and 6.84 MPa, respectively. The HPCM scaffold also exhibited an interconnected porous architecture with porosity greater than 80%, an appropriate degradation rate, and enhanced cell proliferation. Moreover, the HPCM scaffold supported the healing of a rat calvarial defect in vivo.
制造具有足够机械性能的多孔支架是治疗骨缺损的一项挑战。制备了一种由聚左旋乳酸（PLLA）、聚乳酸-乙醇酸共聚物（PLGA）和羟基磷灰石（HA）组成的高压压缩成型（HPCM）多孔复合支架，由于其固体网络结构和高度有序的晶体结构，该支架的机械性能得到了上调。在1000MPa和180°C下成型的HPCM支架的压缩屈服强度和模量分别为0.91MPa和6.84MPa。HPCM支架还呈现出相互连通的多孔结构，孔隙率大于80%，降解速率适宜，细胞增殖增强。此外，HPCM支架在体内支持大鼠颅骨缺损的愈合。
