Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.
Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai 980-8578, Japan.
Toxins (Basel). 2021 Jan 11;13(1):50. doi: 10.3390/toxins13010050.
Nicotinamide adenine dinucleotide (NAD) supplies energy for deoxidation and anti-inflammatory reactions fostering the production of adenosine triphosphate (ATP). The kidney is an essential regulator of body fluids through the excretion of numerous metabolites. Chronic kidney disease (CKD) leads to the accumulation of uremic toxins, which induces chronic inflammation. In this study, the role of NAD in kidney disease was investigated through the supplementation of nicotinamide (Nam), a precursor of NAD, to an adenine-induced CKD mouse model. Nam supplementation reduced kidney inflammation and fibrosis and, therefore, prevented the progression of kidney disease. Notably, Nam supplementation also attenuated the accumulation of glycolysis and Krebs cycle metabolites that occurs in renal failure. These effects were due to increased NAD supply, which accelerated NAD-consuming metabolic pathways. Our study suggests that Nam administration may be a novel therapeutic approach for CKD prevention.
烟酰胺腺嘌呤二核苷酸（NAD）为氧化还原反应和抗炎反应提供能量，促进三磷酸腺苷（ATP）的生成。肾脏通过排泄多种代谢物来调节体液平衡，是人体的重要器官。慢性肾脏病（CKD）会导致尿毒症毒素的积累，从而引发慢性炎症。在这项研究中，通过补充烟酰胺（Nam）——NAD 的前体物质，来治疗腺嘌呤诱导的 CKD 小鼠模型，以此研究 NAD 在肾脏疾病中的作用。Nam 补充剂可减轻肾脏炎症和纤维化，从而阻止肾脏疾病的进展。值得注意的是，Nam 补充剂还可减轻肾衰竭时糖酵解和三羧酸循环代谢物的积累。这些作用归因于 NAD 供应的增加，加速了 NAD 消耗代谢途径。我们的研究表明，Nam 给药可能是预防 CKD 的一种新的治疗方法。
