筛板的临床表现与青光眼性视神经损伤程度的关系。
The clinical appearance of the lamina cribrosa as a function of the extent of glaucomatous optic nerve damage.
作者信息
Miller K M, Quigley H A
机构信息
Glaucoma Service, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
出版信息
Ophthalmology. 1988 Jan;95(1):135-8. doi: 10.1016/s0161-6420(88)33219-7.
The authors evaluated the shapes of the largest clinically visible pores on the surface of the lamina cribrosa in 87 eyes of 52 glaucoma patients and found an apparent progression in pore shape as a function of the extent of glaucomatous optic nerve head damage. Small, round pores predominated in eyes with mild field loss, oval pores were more common in eyes with moderate field loss, and striate or slit-shaped pores were most frequent in eyes with advanced field loss. If the pores of the lamina cribrosa elongate as a function of increasing glaucomatous optic atrophy, and if large pore size is associated with an increased risk for pressure-related axonal damage, then the threshold for ganglion cell atrophy may drop as the damage to the optic nerve progresses.
作者评估了52例青光眼患者87只眼中筛板表面临床上可见的最大孔隙的形状，发现孔隙形状随青光眼性视神经乳头损害程度的变化而呈现明显进展。在视野轻度缺损的眼中，小而圆的孔隙占主导；在视野中度缺损的眼中，椭圆形孔隙更为常见；而在视野重度缺损的眼中，条纹状或裂隙状孔隙最为常见。如果筛板孔隙随着青光眼性视神经萎缩的加重而拉长，并且如果大孔隙尺寸与压力相关轴突损伤风险增加相关，那么随着视神经损害的进展，神经节细胞萎缩的阈值可能会降低。
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