Liu Wenqian, Dong Chengya, Liu Xiangrong
National Center of Clinical Medicine for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
National Center of Clinical Medicine for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China. *Corresponding author, E-mail:
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2021 Jan;37(1):79-83.
Interleukin-4 induced 1 protein (IL4I1), a secreted amino acid oxidase produced by antigen presenting cells, oxidizes phenylalanine to phenylpyruvate. It has been found that IL4I1 exerts an immunosuppressive function by inhibiting the proliferation and differentiation of T cells as well as limiting the proliferation of B cells. IL4I1 is involved in host defense against infection. As a gene related to poor prognosis in cancers, IL4I1 participates in tumor immune escape. IL4I1 promotes remyelination via regulation of the different phenotypes of microglia in the autoimmune demyelinating diseases, but the detailed mechanism still remains unknown. We summarize the role and mechanism of IL4I1 in the immune regulation to provide new ideas for the treatment of infections, cancers and autoimmune diseases.
白细胞介素-4诱导蛋白1（IL4I1）是一种由抗原呈递细胞分泌的氨基酸氧化酶，可将苯丙氨酸氧化为苯丙酮酸。研究发现，IL4I1通过抑制T细胞的增殖和分化以及限制B细胞的增殖发挥免疫抑制功能。IL4I1参与宿主抗感染防御。作为一种与癌症预后不良相关的基因，IL4I1参与肿瘤免疫逃逸。在自身免疫性脱髓鞘疾病中，IL4I1通过调节小胶质细胞的不同表型促进髓鞘再生，但其具体机制仍不清楚。我们总结了IL4I1在免疫调节中的作用和机制，为感染性疾病、癌症和自身免疫性疾病的治疗提供新思路。
