Fourie P R, Joubert J R
Department of Medical Physiology, University of Stellenbosch, Tygerberg, South Africa.
Pediatr Pulmonol. 1988 Jan-Feb;4(1):2-7. doi: 10.1002/ppul.1950040103.
An easy and accurate method of assessing bronchial hyper-reactivity could be of great value in identifying and classifying the degree of severity of asthma in children. The sensitivity and specificity of three methods of provocation, ie, histamine, nebulized water, and exercise, were compared in 20 asthmatic and 20 control children between ages 5 and 13 years. Three clinical categories of severity ranging from slight (Group 1) through moderate (Group 2) to severe asthma (Group 3) were identified. The three methods were compared in each subgroup for detecting a tendency to bronchospasm. An inverse correlation (-0.57) was found between the histamine dose and clinical degree of severity, whereas distilled water and exercise proved to be too insensitive for identifying Group 1 asthmatics. Histamine challenge in children is a safe and sensitive technique for identifying asthma and for monitoring the severity of the disease during follow-up.
一种简便且准确的评估支气管高反应性的方法，对于识别和划分儿童哮喘的严重程度具有重要价值。在20名5至13岁的哮喘儿童和20名对照儿童中，比较了三种激发方法（即组胺、雾化水和运动）的敏感性和特异性。确定了从轻度（第1组）到中度（第2组）再到重度哮喘（第3组）的三个临床严重程度类别。在每个亚组中比较这三种方法以检测支气管痉挛的倾向。发现组胺剂量与临床严重程度之间呈负相关（-0.57），而蒸馏水和运动被证明对于识别第1组哮喘儿童过于不敏感。儿童组胺激发试验是一种安全且敏感的技术，可用于识别哮喘并在随访期间监测疾病的严重程度。
