Department of Epidemiology, School of Public Health and Management, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, 400016, China.
Chongqing Nan'an District People's Hospital, Chongqing, China.
Sci Rep. 2021 Jan 13;11(1):907. doi: 10.1038/s41598-020-79282-2.
Aim to compare the home blood pressure monitoring (HBPM) and visit blood pressure monitoring in a clinical phase I single-arm pilot trial. The 18% sodium substitute salt was used in 43 hypertensives for 8 weeks, and visited once a week, while weekly visit blood (VBP) pressure, daily home blood pressure (HBP) and urine test results before and after intervention were collected. 43 hypertensive patients were recruited, 4 were lost. And enrolled 39 patients for analysis. The VBP were lower than morning HBP and night HBP (P < 0.05). And VBP was good correlated with morning BP (SBP: r = 0.692, P < 0.001, DBP: r = 0.789, P < 0.001) and night BP (SBP: r = 0.571, P < 0.001, DBP: r = 0.738, P < 0.001). The results of mixed linear model analysis showed that patients' visit SBP (- 11.4 mmHg, 95% CI: - 17.0 to - 5.7, P < 0.001), morning home SBP (- 10.0 mmHg, 95% CI: - 16.4 to - 3.6, P = 0.003) and night home SBP (- 10.2 mmHg, 95% CI: - 15.8 to - 4.6, P = 0.001) decreased significantly, after intervention. Both HBP and VBP showed that 18% substitute salt intervention could decrease the blood pressure of hypertensives. Medication led to VBP lower than HBP, but the two still had a good correlation.Trial registration: NCT03226327. Registered 21 July 2017-Retrospectively registered, http://www.clinicaltrials.gov .
目的是比较临床 I 期单臂试验中家庭血压监测（HBPM）和就诊血压监测。在 43 例高血压患者中使用 18%的代盐 8 周，每周就诊一次，同时收集干预前后每周就诊血压（VBP）、每日家庭血压（HBP）和尿液检测结果。共招募了 43 例高血压患者，其中 4 例失访，纳入 39 例患者进行分析。VBP 低于早晨 HBP 和夜间 HBP（P<0.05）。VBP 与早晨 BP（SBP：r=0.692，P<0.001，DBP：r=0.789，P<0.001）和夜间 BP（SBP：r=0.571，P<0.001，DBP：r=0.738，P<0.001）呈良好相关性。混合线性模型分析结果显示，患者就诊 SBP 降低（-11.4mmHg，95%CI：-17.0 至-5.7，P<0.001），早晨家庭 SBP 降低（-10.0mmHg，95%CI：-16.4 至-3.6，P=0.003）和夜间家庭 SBP 降低（-10.2mmHg，95%CI：-15.8 至-4.6，P=0.001），干预后差异有统计学意义。HBPM 和 VBP 均显示 18%替代盐干预可降低高血压患者血压。药物治疗导致 VBP 低于 HBP，但两者仍具有良好的相关性。试验注册：NCT03226327。2017 年 7 月 21 日注册-回顾性注册，http://www.clinicaltrials.gov。
