Lat Annabelle Marie, Jauculan Maria Cristina, Sanchez Charisse Ann, Jimeno Cecilia, Sison-Peña Cherrie Mae, Pe-Yan Mary Rose, Pagkatipunan Paulo Ma, Suller Armida, Cena Marianne
Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of the Philippines Manila-Philippine General Hospital.
Section of Plastic-Lacrimal and Orbit, Department of Ophthalmology and Visual Sciences, University of the Philippines Manila-Philippine General Hospital.
J ASEAN Fed Endocr Soc. 2017;32(2):151-157. doi: 10.15605/jafes.032.02.09. Epub 2017 Sep 7.
Asians with Graves' ophthalmopathy (GO) may have earlier compressive features due to narrower orbital apex and increased orbital volume.
To determine the risk factors associated with activity and severity of GO among adults.
This was a cross-sectional analytical study of 163 adults with Graves' disease (GD) from the outpatient clinics of the Philippine General Hospital. Demographics, clinical data, thyrotropin receptor antibody (TRAb) and urine iodine (UIE) levels were obtained. All participants were evaluated for activity and severity of GO by a single ophthalmologist.
The population was predominantly composed of females (81%) and nonsmokers (69%), with a mean age of 35 + 11 years and median GD duration of 2 years. Median TRAb was 8.9 U/L while UIE was 171 mcg/L. Eight percent exhibited active GO, with 85% having mild disease. Multivariate analysis showed male sex to be associated with severe disease (OR 3.71, =0.041), while elevated TRAb was associated with both active (OR 1.03, =0.002) and severe GO (OR 1.02, =0.007).
Lower rates of active and severe GO were seen compared to previous reports. In this population of predominantly nonsmokers, elevated TRAb emerged as a risk factor for active and severe GO.
患有格雷夫斯眼病（GO）的亚洲人可能因眶尖较窄和眶容积增加而更早出现压迫症状。
确定成年人中与GO活动度和严重程度相关的危险因素。
这是一项对菲律宾总医院门诊的163例格雷夫斯病（GD）成年患者进行的横断面分析研究。收集了人口统计学、临床数据、促甲状腺素受体抗体（TRAb）和尿碘（UIE）水平。所有参与者均由一名眼科医生评估GO的活动度和严重程度。
研究人群主要为女性（81%）和非吸烟者（69%），平均年龄为35±11岁，GD病程中位数为2年。TRAb中位数为8.9 U/L，UIE为171 mcg/L。8%的患者表现为活动性GO，其中85%为轻度疾病。多变量分析显示男性与严重疾病相关（OR 3.71，P=0.041），而TRAb升高与活动性GO（OR 1.03，P=0.002）和严重GO（OR 1.02，P=0.007）均相关。
与既往报告相比，活动性和严重GO的发生率较低。在这个以非吸烟者为主的人群中，TRAb升高是活动性和严重GO的一个危险因素。
