Vintimilla Raul, Balasubramanian Kishore, Hall James, Johnson Leigh, O'Bryant Sid
Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Department of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Dement Geriatr Cogn Dis Extra. 2020 Nov 16;10(3):154-162. doi: 10.1159/000511103. eCollection 2020 Sep-Dec.
The present study sought to evaluate the contribution of cardiovascular risk factors to cognitive functioning in a sample of Mexican Americans diagnosed with mild cognitive impairment (MCI).
Hypertension, diabetes, dyslipidemia, and obesity were diagnosed based on self-report and/or standardized procedures. Cognitive function was measured with MMSE, Logical Memory I and II, Trail A & B, FAS, animal naming, and digit span tests. Independent samples tests and two-way ANOVAs were conducted for analyses, adjusting for relevant covariates. We studied 100 Mexican Americans (65 female) with MCI, ages 50-86, from a longitudinal study of cognitive aging conducted at the University of North Texas Health Science Center.
A difference between subjects with and without obesity and memory scores was shown by tests. Two-way ANOVAs detected an association between the coexistence of hypertension and diabetes with language measures, diabetes and dyslipidemia with executive function, and diabetes and obesity with memory and language measures.
This study provides additional evidence about the link between cardiovascular risk factors and cognitive dysfunction in MCI subjects, and also demonstrated that comorbid risk factors increased the degree of cognitive deficit in many areas, which may indicate a higher risk of developing dementia.
本研究旨在评估心血管危险因素对被诊断为轻度认知障碍（MCI）的墨西哥裔美国人样本认知功能的影响。
高血压、糖尿病、血脂异常和肥胖症通过自我报告和/或标准化程序进行诊断。认知功能通过简易精神状态检查表（MMSE）、逻辑记忆I和II、连线测验A和B、FAS、动物命名和数字广度测试进行测量。进行独立样本检验和双向方差分析以进行分析，并对相关协变量进行调整。我们从北德克萨斯大学健康科学中心进行的一项认知衰老纵向研究中选取了100名年龄在50 - 86岁之间的患有MCI的墨西哥裔美国人（65名女性）。
通过检验显示，有肥胖和无肥胖的受试者在记忆分数上存在差异。双向方差分析检测到高血压和糖尿病共存与语言测量之间、糖尿病和血脂异常与执行功能之间、糖尿病和肥胖与记忆及语言测量之间存在关联。
本研究为心血管危险因素与MCI受试者认知功能障碍之间的联系提供了更多证据，并且还表明合并的危险因素在许多方面增加了认知缺陷的程度，这可能表明患痴呆症的风险更高。
