Vintimilla Raul, Mathew Ezek, Hall James, Johnson Leigh, O'Bryant Sid
University of North Texas Health Science Center - Institute for Translational Research, 855 Montgomery St, Fort Worth, Texas, 76107.
University of North Texas Health Science Center - Texas College of Osteopathic medicine, 3500 Camp Bowie Blvd, Fort Worth, Texas, 76107.
Cereb Circ Cogn Behav. 2022 Mar 4;3:100126. doi: 10.1016/j.cccb.2022.100126. eCollection 2022.
Subjective cognitive complaints (SCC) are associated with higher risk of mild cognitive impairment (MCI) and dementia. Cardiovascular risk factors (CVRF) have been also associated with cognitive decline, MCI, and dementia. Few studies have examined the associated of CVRF and SCC.
Participants were cognitively normal Mexican Americans from the HABLE study. Participants were categorized as with and without SCC, and SCC was also measured as a continuous variable. CVRF diagnosis were ascertained during consensus review. Cognitive measures used were MMSE, Trails B, SEVLT, and digit span. Logistic regression and linear regression were used to asses the association of SCC with CVRF and cognitive scores.
A total of 673 participants [mean age 63.3 (SD=7.71), 69.2% female] were included. SCC was present in 323 participants (47.99%). Dyslipidemia and depression were associated with SCC. Individuals with dyslipidemia had 1.72 times the odds (95% CI = 1.20 to 2.47) of SCC, and those with depression had 3.15 times the odds (95% CI = 2.16 to 4.59) of self-reporting SCC. Higher SCC scores, were significantly associated with MMSE (B = 0.07; SE = 0.03; p = 0.02), and SEVLT immediate and delayed (B= -0.03; SE = 0.00; p = 0.000 and B = -0.03; SE = 0.00; p = 0.000, respectively).
In a cognitively normal Mexican Americans sample of older adults, depression and dyslipidemia were correlated with self-reported SCC. A greater self-perception of cognitive decline correlated with lower scores on the MMSE and SEVLT.
主观认知主诉（SCC）与轻度认知障碍（MCI）和痴呆的较高风险相关。心血管危险因素（CVRF）也与认知能力下降、MCI和痴呆有关。很少有研究探讨CVRF与SCC之间的关联。
参与者是来自HABLE研究的认知正常的墨西哥裔美国人。参与者被分为有和没有SCC两组，SCC也作为一个连续变量进行测量。在共识审查期间确定CVRF诊断。使用的认知测量方法有简易精神状态检查表（MMSE）、连线测验B、语义相关词语学习测验（SEVLT）和数字广度测验。采用逻辑回归和线性回归来评估SCC与CVRF及认知分数之间的关联。
共纳入673名参与者[平均年龄63.3（标准差=7.71），69.2%为女性]。323名参与者（47.99%）存在SCC。血脂异常和抑郁症与SCC相关。血脂异常者出现SCC的几率是正常人的1.72倍（95%置信区间=1.20至2.47），而抑郁症患者自我报告SCC的几率是正常人的3.15倍（95%置信区间=2.16至4.59）。较高的SCC分数与MMSE（B=0.07；标准误=0.03；p=0.02）以及SEVLT即时和延迟成绩显著相关（B=-0.03；标准误=0.00；p=0.000和B=-0.03；标准误=0.00；p=0.000）。
在一个认知正常的老年墨西哥裔美国人样本中，抑郁症和血脂异常与自我报告的SCC相关。对认知能力下降的更强自我认知与MMSE和SEVLT的较低分数相关。
