Liu Shiyu, Zhao Qin, Shi Weiyan, Zheng Zhuangzhuang, Liu Zijing, Meng Lingbin, Dong Lihua, Jiang Xin
Department of Radiation Oncology, The First Hospital of Jilin University, Changchun 130021, China.
Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University, Changchun 130021, China.
J Cancer. 2021 Jan 1;12(4):1094-1104. doi: 10.7150/jca.51107. eCollection 2021.
High-grade gliomas (HGGs) are the most common primary malignant brain tumors. They have a high degree of malignancy and show invasive growth. The personal treatment plan for HGG is based on the patient's age, performance status, and degree of tumor invasion. The basic treatment plan for HGG involves tumor resection, radiotherapy (RT) with concomitant temozolomide (TMZ), and adjuvant TMZ chemotherapy. The basic radiation technology includes conventional RT, three-dimensional conformal RT, intensity-modulated RT, and stereotactic RT. As our understanding of tumor pathogenesis has deepened, so-called comprehensive treatment schemes have attracted attention. These combine RT with chemotherapy, molecular targeted therapy, immunotherapy, or tumor-treating fields. These emerging treatments are expected to improve the prospects of patients with HGG. In the present article, we review the recent advances in RT and comprehensive treatment for patients with newly diagnosed and recurrent HGG.
高级别胶质瘤（HGGs）是最常见的原发性恶性脑肿瘤。它们具有高度的恶性，并呈浸润性生长。HGG的个体化治疗方案基于患者的年龄、身体状况和肿瘤浸润程度。HGG的基本治疗方案包括肿瘤切除、同步使用替莫唑胺（TMZ）的放射治疗（RT）以及辅助性TMZ化疗。基本的放射技术包括传统RT、三维适形RT、调强RT和立体定向RT。随着我们对肿瘤发病机制的理解不断深入，所谓的综合治疗方案受到了关注。这些方案将RT与化疗、分子靶向治疗、免疫治疗或肿瘤治疗电场相结合。这些新兴治疗方法有望改善HGG患者的预后。在本文中，我们综述了新诊断和复发HGG患者RT及综合治疗的最新进展。
