Liu Shiyu, Dong Lihua, Shi Weiyan, Zheng Zhuangzhuang, Liu Zijing, Meng Lingbin, Xin Ying, Jiang Xin
Jilin Provincial Key Laboratory of Radiation Oncology and Therapy, The First Hospital of Jilin University, Changchun, China.
Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, China.
Front Pharmacol. 2022 Jul 22;13:921070. doi: 10.3389/fphar.2022.921070. eCollection 2022.
Oxidative stress refers to the imbalance between oxidation and antioxidant activity in the body. Oxygen is reduced by electrons as part of normal metabolism leading to the formation of various reactive oxygen species (ROS). ROS are the main cause of oxidative stress and can be assessed through direct detection. Oxidative stress is a double-edged phenomenon in that it has protective mechanisms that help to destroy bacteria and pathogens, however, increased ROS accumulation can lead to host cell apoptosis and damage. Glioma is one of the most common malignant tumors of the central nervous system and is characterized by changes in the redox state. Therapeutic regimens still encounter multiple obstacles and challenges. Glioma occurrence is related to increased free radical levels and decreased antioxidant defense responses. Oxidative stress is particularly important in the pathogenesis of gliomas, indicating that antioxidant therapy may be a means of treating tumors. This review evaluates oxidative stress and its effects on gliomas, describes the potential targets and therapeutic drugs in detail, and clarifies the effects of radiotherapy and chemotherapy on oxidative stress. These data may provide a reference for the development of precise therapeutic regimes of gliomas based on oxidative stress.
氧化应激是指体内氧化与抗氧化活性之间的失衡。作为正常新陈代谢的一部分，氧气通过电子还原，导致各种活性氧（ROS）的形成。ROS是氧化应激的主要原因，可通过直接检测进行评估。氧化应激是一种双刃剑现象，因为它具有有助于破坏细菌和病原体的保护机制，然而，ROS积累增加会导致宿主细胞凋亡和损伤。胶质瘤是中枢神经系统最常见的恶性肿瘤之一，其特征是氧化还原状态发生变化。治疗方案仍然面临多重障碍和挑战。胶质瘤的发生与自由基水平升高和抗氧化防御反应降低有关。氧化应激在胶质瘤的发病机制中尤为重要，这表明抗氧化治疗可能是一种治疗肿瘤的手段。本综述评估了氧化应激及其对胶质瘤的影响，详细描述了潜在靶点和治疗药物，并阐明了放疗和化疗对氧化应激的影响。这些数据可能为基于氧化应激的胶质瘤精确治疗方案的开发提供参考。
