Montesano Giovanni, Ometto Giovanni, Higgins Bethany E, Iester Costanza, Balaskas Konstantinos, Tufail Adnan, Chakravarthy Usha, Hogg Ruth E, Crabb David P
City, University of London-Optometry and Visual Sciences, London, UK.
NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.
Transl Vis Sci Technol. 2020 Dec 28;9(13):43. doi: 10.1167/tvst.9.13.43. eCollection 2020 Dec.
To investigate the structure-function relationship in eyes with drusen with mesopic and scotopic microperimetry.
We analyzed structural and functional data from 43 eyes with drusen. Functional data were acquired with mesopic and scotopic two-color (red and cyan) microperimetry. Normative values were calculated using data from 56 healthy eyes. Structural measurements were green autofluorescence and dense macular optical coherence tomography scans. The latter were used to calculate the retinal pigment epithelium elevation (RPE-E) and the photoreceptor reflectivity ratio (PRR). The pointwise structure-function relationship was measured with linear mixed models having the log-transformed structural parameters as predictors and the sensitivity loss (SL, deviation from normal) as the response variable.
In the univariable analysis, the structural predictors were all significantly correlated ( < 0.05) with the SL in the mesopic and scotopic tests. In a multivariable model, mesopic microperimetry yielded the best structure-function relationship. All predictors were significant ( < 0.05), but the predictive power was weak (best = 0.09). The relationship was improved when analyzing locations with abnormal RPE-E (best = 0.18).
Mesopic microperimetry shows better structure-function relationship compared to scotopic microperimetry; the relationship is weak, likely due to the early functional damage and the small number of tested locations affected by drusen. The relationship is stronger when locations with drusen are isolated for the mesopic and scotopic cyan test.
These results could be useful to devise integrated structure-function methods to detect disease progression in intermediate age-related macular degeneration.
采用中视和暗视微视野检查法研究伴有玻璃膜疣的眼睛的结构-功能关系。
我们分析了43只伴有玻璃膜疣的眼睛的结构和功能数据。使用中视和暗视双色（红色和青色）微视野检查法获取功能数据。使用56只健康眼睛的数据计算正常值。结构测量包括绿色自发荧光和密集黄斑光学相干断层扫描。后者用于计算视网膜色素上皮隆起（RPE-E）和光感受器反射率比（PRR）。采用线性混合模型测量逐点结构-功能关系，将对数转换后的结构参数作为预测因子，将敏感度损失（SL，与正常的偏差）作为响应变量。
在单变量分析中，在中视和暗视测试中，结构预测因子与SL均显著相关（<0.05）。在多变量模型中，中视微视野检查产生了最佳的结构-功能关系。所有预测因子均具有显著性（<0.05），但预测能力较弱（最佳=0.09）。在分析RPE-E异常的部位时，这种关系得到了改善（最佳=0.18）。
与暗视微视野检查相比，中视微视野检查显示出更好的结构-功能关系；这种关系较弱，可能是由于早期功能损害以及受玻璃膜疣影响的测试部位数量较少。在中视和暗视青色测试中分离出有玻璃膜疣的部位时，这种关系更强。
这些结果可能有助于设计综合的结构-功能方法，以检测中度年龄相关性黄斑变性的疾病进展。
