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使用消费级可穿戴设备预测下肢手术后的主观恢复情况。

Predicting Subjective Recovery from Lower Limb Surgery Using Consumer Wearables.

作者信息

Karas Marta, Marinsek Nikki, Goldhahn Jörg, Foschini Luca, Ramirez Ernesto, Clay Ieuan

机构信息

Evidation Health Inc., San Mateo, California, USA.

Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.

出版信息

Digit Biomark. 2020 Nov 26;4(Suppl 1):73-86. doi: 10.1159/000511531. eCollection 2020 Winter.

Abstract

INTRODUCTION

A major challenge in the monitoring of rehabilitation is the lack of long-term individual baseline data which would enable accurate and objective assessment of functional recovery. Consumer-grade wearable devices enable the tracking of individual everyday functioning prior to illness or other medical events which necessitate the monitoring of recovery trajectories.

METHODS

For 1,324 individuals who underwent surgery on a lower limb, we collected their Fitbit device data of steps, heart rate, and sleep from 26 weeks before to 26 weeks after the self-reported surgery date. We identified subgroups of individuals who self-reported surgeries for bone fracture repair ( = 355), tendon or ligament repair/reconstruction ( = 773), and knee or hip joint replacement ( = 196). We used linear mixed models to estimate the average effect of time relative to surgery on daily activity measurements while adjusting for gender, age, and the participant-specific activity baseline. We used a sub-cohort of 127 individuals with dense wearable data who underwent tendon/ligament surgery and employed XGBoost to predict the self-reported recovery time.

RESULTS

The 1,324 study individuals were all US residents, predominantly female (84%), white or Caucasian (85%), and young to middle-aged (mean age 36.2 years). We showed that 12 weeks pre- and 26 weeks post-surgery trajectories of daily behavioral measurements (steps sum, heart rate, sleep efficiency score) can capture activity changes relative to an individual's baseline. We demonstrated that the trajectories differ across surgery types, recapitulate the documented effect of age on functional recovery, and highlight differences in relative activity change across self-reported recovery time groups. Finally, using a sub-cohort of 127 individuals, we showed that long-term recovery can be accurately predicted, on an individual level, only 1 month after surgery (AUROC 0.734, AUPRC 0.8). Furthermore, we showed that predictions are most accurate when long-term, individual baseline data are available.

DISCUSSION

Leveraging long-term, passively collected wearable data promises to enable relative assessment of individual recovery and is a first step towards data-driven intervention for individuals.

摘要

引言

康复监测中的一个主要挑战是缺乏长期的个体基线数据,而这些数据能够对功能恢复进行准确和客观的评估。消费级可穿戴设备能够追踪个体在患病或其他需要监测恢复轨迹的医疗事件之前的日常功能。

方法

对于1324名接受下肢手术的个体,我们收集了他们在自我报告的手术日期前26周和后26周的Fitbit设备的步数、心率和睡眠数据。我们确定了自我报告进行骨折修复手术(n = 355)、肌腱或韧带修复/重建手术(n = 773)以及膝关节或髋关节置换手术(n = 196)的个体亚组。我们使用线性混合模型来估计相对于手术时间对日常活动测量的平均影响,同时对性别、年龄和参与者特定的活动基线进行调整。我们使用了127名接受肌腱/韧带手术且有密集可穿戴数据的个体亚组,并采用极端梯度提升(XGBoost)来预测自我报告的恢复时间。

结果

1324名研究个体均为美国居民,主要为女性(84%),白人或高加索人(85%),年龄在青年到中年之间(平均年龄36.2岁)。我们表明,手术前12周和手术后26周的日常行为测量轨迹(步数总和、心率、睡眠效率得分)能够捕捉相对于个体基线的活动变化。我们证明了不同手术类型的轨迹存在差异,概括了年龄对功能恢复的已记录影响,并突出了自我报告的恢复时间组之间相对活动变化的差异。最后,使用127名个体的亚组,我们表明在手术后仅1个月就能在个体层面准确预测长期恢复情况(受试者工作特征曲线下面积为0.734,精确召回率曲线下面积为0.8)。此外,我们表明当有长期的个体基线数据时,预测最为准确。

讨论

利用长期被动收集的可穿戴数据有望实现对个体恢复的相对评估,并且是迈向针对个体的数据驱动干预的第一步。

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