Chair of Epidemiology, Ludwig-Maximilians-Universität München, UNIKA-T Augsburg, Neusässer Str. 47, 86156, Augsburg, Germany.
Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Eur J Clin Pharmacol. 2021 Jul;77(7):1039-1048. doi: 10.1007/s00228-020-03068-8. Epub 2021 Jan 13.
Due to conflicting scientific evidence for an increased risk of dementia by intake of proton pump inhibitors (PPIs), this study investigates associations between PPI use and brain volumes, estimated brain age, and cognitive function in the general population.
Two surveys of the population-based Study of Health in Pomerania (SHIP) conducted in Northeast Germany were used. In total, 2653 participants underwent brain magnetic resonance imaging (MRI) and were included in the primary analysis. They were divided into two groups according to their PPI intake and compared with regard to their brain volumes (gray matter, white matter, total brain, and hippocampus) and estimated brain age. Multiple regression was used to adjust for confounding factors. Cognitive function was evaluated by the Verbal Learning and Memory Test (VLMT) and the Nuremberg Age Inventory (NAI) and put in relation to PPI use.
No association was found between PPI use and brain volumes or the estimated brain age. The VLMT score was 1.11 lower (95% confidence interval: - 2.06 to - 0.16) in immediate recall, and 0.72 lower (95% CI: - 1.22 to - 0.22) in delayed recall in PPI users than in non-users. PPI use was unrelated to the NAI score.
The present study does not support a relationship between PPI use and brain aging.
由于质子泵抑制剂 (PPI) 摄入增加痴呆风险的科学证据相互矛盾，本研究调查了 PPI 使用与大脑体积、估计脑龄和认知功能之间的关联在普通人群中。
使用德国东北部基于人群的什未林健康研究 (SHIP) 的两项调查。共有 2653 名参与者接受了脑部磁共振成像 (MRI) 检查，并纳入了主要分析。他们根据 PPI 的摄入量分为两组，并比较了他们的大脑体积（灰质、白质、总脑和海马体）和估计的脑龄。多元回归用于调整混杂因素。认知功能通过言语学习和记忆测试 (VLMT) 和纽伦堡年龄量表 (NAI) 进行评估，并与 PPI 使用相关联。
PPI 使用与大脑体积或估计的脑龄之间没有关联。在即时回忆中，PPI 使用者的 VLMT 评分比非使用者低 1.11（95%置信区间：-2.06 至 -0.16），在延迟回忆中低 0.72（95%CI：-1.22 至 -0.22）。PPI 使用与 NAI 评分无关。
本研究不支持 PPI 使用与大脑衰老之间的关系。
