School of Veterinary Medicine, Murdoch University, Perth, Western Australia, Australia.
Aust Vet J. 2021 Apr;99(4):119-123. doi: 10.1111/avj.13050. Epub 2021 Jan 13.
Brain metastases are well known for disseminated hemangiosarcoma involving the right atrium/auricle.
An 8-year-old male Australian Shepherd Dog presented with a 3-day history of circling to the left. A neurological examination revealed obtunded mentation, right hemi-inattention, bilateral strabismus towards the left side and absent physiological nystagmus. In addition, the dog had muffled heart sounds on auscultation and exercise-induced weakness. Laboratory findings included hypercoagulability and marked elevation in the C-reactive protein concentration. Electrocardiography detected a sinus rhythm with right bundle-branch block and ventricular bigeminy. Echocardiography revealed an extensive interventricular septal mass. Due to the grave prognosis, the owners elected for euthanasia, and a complete necropsy was performed. The main pathological findings were an interventricular septal and left ventricular hemangiosarcoma, with metastases in the brain, lungs, spleen and adrenal glands. No evidence of tumour infiltration was found in the right atrium.
To the authors' knowledge, this is the first report of neurological signs due to confirmed brain metastases in a dog with interventricular septal hemangiosarcoma. Although the right atrium is the main location for cardiac hemangiosarcoma, the interventricular septum should be evaluated in all cases.
右心房/心耳播散性血管肉瘤易发生脑转移，这是众所周知的。
一只 8 岁雄性澳大利亚牧羊犬出现 3 天的向左转圈症状。神经学检查显示精神沉郁、右半身忽视、双侧斜视向左和生理性眼球震颤消失。此外，听诊时心音低沉，运动时出现虚弱。实验室检查结果包括高凝状态和 C 反应蛋白浓度显著升高。心电图显示窦性节律伴右束支传导阻滞和室性二联律。超声心动图显示广泛的室间隔肿块。由于预后严重，主人选择安乐死，并进行了全面尸检。主要的病理发现是室间隔和左心室血管肉瘤，伴有脑、肺、脾和肾上腺转移。右心房未发现肿瘤浸润的证据。
据作者所知，这是首例报道的犬室间隔血管肉瘤伴脑转移引起的神经症状。虽然右心房是心脏血管肉瘤的主要部位，但应在所有病例中评估室间隔。
