Department of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA.
Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Immunology. 2021 Feb;162(2):121-122. doi: 10.1111/imm.13301.
In this issue, we introduce the second part of a series of reviews focusing on how immunometabolism influences host and pathogen interactions during infection. This part of the collection addresses the interface between metabolism and specific types of infection, including immunometabolism in macrophages during helminth infection, the role of metabolism in T-cell exhaustion during chronic viral infections and host immunometabolism in the defence against Mycobacterium tuberculosis infection. These reviews, together with the four articles published in part 1 of the series in November 2020, offer new insights into the complex interactions between mammalian hosts and microbial pathogens through the lens of cellular metabolic regulation.
本期内容为一系列综述的第二部分，主要聚焦于免疫代谢如何影响宿主与病原体在感染过程中的相互作用。本辑综述涵盖了代谢与特定类型感染之间的联系，包括蠕虫感染时巨噬细胞中的免疫代谢、慢性病毒感染中 T 细胞耗竭的代谢作用，以及宿主针对结核分枝杆菌感染的免疫代谢。这些综述与 2020 年 11 月出版的第一部分中的四篇文章一起，为我们理解哺乳动物宿主与微生物病原体之间的复杂相互作用提供了新视角，其切入点为细胞代谢调控。
