Hafner R, Schär G
Institut für Medizinische Mikrobiologie, Universität Zürich.
Schweiz Med Wochenschr. 1988 Jan 16;118(2):42-8.
The correlation of Cand-Tec (candida antigen detection) with clinical findings and results in passive hemagglutination and immunoelectrophoresis (antibody detection) has been evaluated retrospectively. Based on mycological findings, 33 patients with a Cand-Tec titer were classified into five groups. Systemic antimycotic therapy was another criterion. Using a titer of greater than or equal to 1:8 as diagnostic of systemic or local candidal infection, the positive predictive value was 33% and 55% respectively. However, a titer of greater than or equal to 1:8 correlated significantly (p less than 0.05) with infection (systemic, presumably systemic and local candidiasis, n = 3). The combined findings of an antigen titer of greater than or equal to 1:8 and antibodies to cytoplasmatic protein antigens of candida correlated even better with infection (p less than 0.02) and had a positive predictive value of 100%. Antigen and antibody determination may be useful adjunctive procedures in the diagnosis of candida infections.
对Cand - Tec（念珠菌抗原检测）与临床发现以及被动血凝试验和免疫电泳（抗体检测）结果之间的相关性进行了回顾性评估。根据真菌学检查结果，33例有Cand - Tec滴度的患者被分为五组。全身抗真菌治疗是另一个标准。以滴度大于或等于1:8作为系统性或局部念珠菌感染的诊断标准，阳性预测值分别为33%和55%。然而，滴度大于或等于1:8与感染（系统性、可能的系统性和局部念珠菌病，n = 3）有显著相关性（p小于0.05）。抗原滴度大于或等于1:8与念珠菌细胞质蛋白抗原抗体的联合检测结果与感染的相关性更好（p小于0.02），阳性预测值为100%。抗原和抗体检测可能是念珠菌感染诊断中有用的辅助检查方法。
