Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Department of Organic Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Int J Biol Macromol. 2021 Mar 1;172:55-65. doi: 10.1016/j.ijbiomac.2021.01.037. Epub 2021 Jan 11.
In this content, a green approach for the ultrasound promoted in situ immobilization of Pd NPs over biodegradable chitosan/agarose modified ferrite NP (FeO@CS-Agarose/Pd) is developed. The structural and physicochemical features of the material were estimated using advanced analytical techniques like FT-IR, ICP-OES, FESEM, EDS, XRD, TEM and VSM. The magnetic material was catalytically explored in the oxidation of alcohols under ultrasonic waves. Sonication had a significant role in enhancing the catalytic performance in the alcohol's oxidation as compared to conventional heating. The heterogeneous nanocatalyst was efficiently recycled up to 10 times with nominal loss in catalytic activity. Towards the biological applications, the FeO@CS-Agarose/Pd nanocomposite showed high antioxidant activities against DPPH free radicals, comparable to standard butylated hydroxytoluene (BHT). In addition, it exhibited excellent cytotoxicity in terms of % cell viability against breast adenocarcinoma (MCF7), breast carcinoma (Hs 578Bst), infiltrating ductal cell carcinoma (Hs 319.T), and metastatic carcinoma (MDA-MB-453) cell lines. The best anti-breast cancer potential of the nanocomposite was observed in Hs 319.T cell line.
本文开发了一种绿色方法，通过超声促进 Pd NPs 在可生物降解的壳聚糖/琼脂糖修饰的铁氧体 NP（FeO@CS-Agarose/Pd）上原位固定。采用先进的分析技术，如 FT-IR、ICP-OES、FESEM、EDS、XRD、TEM 和 VSM，对材料的结构和物理化学性质进行了评估。该磁性材料在超声波作用下用于醇的氧化反应中进行了催化研究。与传统加热相比，超声在醇氧化中的催化性能有显著提高。非均相纳米催化剂可高效回收 10 次，催化活性损失较小。在生物应用方面，FeO@CS-Agarose/Pd 纳米复合材料对 DPPH 自由基显示出高抗氧化活性，与标准丁基化羟基甲苯（BHT）相当。此外，它在细胞活力方面对乳腺腺癌（MCF7）、乳腺导管癌（Hs 578Bst）、浸润性导管细胞癌（Hs 319.T）和转移性癌（MDA-MB-453）细胞系表现出优异的细胞毒性。该纳米复合材料在 Hs 319.T 细胞系中表现出最佳的抗乳腺癌潜力。
