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BNCT 治疗滑膜肉瘤。

BNCT for primary synovial sarcoma.

机构信息

Department of Orthopaedic Surgery, Hyogo Cancer Center, Japan; Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Japan.

Institute for Integrated Radiation and Nuclear Science, Kyoto University, Japan.

出版信息

Appl Radiat Isot. 2021 Mar;169:109407. doi: 10.1016/j.apradiso.2020.109407. Epub 2020 Dec 29.

Abstract

Synovial sarcoma is a rare tumor requiring new treatment methods. A 46-year-old woman with primary monophasic synovial sarcoma in the left thigh involving the sciatic nerve, declining surgery because of potential dysfunction of the affected limbs, received two courses of BNCT. The tumor thus reduced was completely resected with no subsequent recurrence. The patient is now able to walk unassisted, and no local recurrence has been observed, demonstrating the applicability of BNCT as adjuvant therapy for synovial sarcoma. Further study and analysis with more experience accumulation are needed to confirm the real impact of BNCT efficacy for its application to synovial sarcoma.

摘要

滑膜肉瘤是一种罕见的肿瘤,需要新的治疗方法。一位 46 岁的女性患者,左大腿原发性单相滑膜肉瘤累及坐骨神经,由于受累肢体潜在功能障碍而拒绝手术,接受了 2 个疗程的硼中子俘获治疗(BNCT)。肿瘤缩小后,患者接受了完全切除,没有复发。患者现在能够独立行走,没有局部复发,表明 BNCT 作为滑膜肉瘤辅助治疗的适用性。需要进一步的研究和分析,积累更多的经验,以确认 BNCT 对滑膜肉瘤治疗效果的实际影响。

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