Department of maternal, child and adolescent health, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China.
J Affect Disord. 2021 Mar 1;282:627-636. doi: 10.1016/j.jad.2020.12.114. Epub 2020 Dec 31.
Polygenic risk score (PRS) is a method of revealing multiple genes effect. The study of PRS and childhood trauma (CT) and resilience on adolescent depressive symptoms are fewer reported, especially the functional mechanism of resilience among them.
718 Chinese adolescents aged 10-14 years were surveyed including CT, resilience, depressive symptoms, and phenotype data in three years of the cohort study. PRS was calculated by the weighted accumulation effects of alleles on depressive symptoms. Their relationships were analyzed by the mediation and moderation models.
PRS and CT were risk factors for depressive symptoms. Interaction (PRS × CT) on depressive symptoms had no statistical significance. Resilience acted as the protective mediator from CT (emotional abuse, emotional neglect, physical neglect) to depressive symptoms and moderator from CT (emotional abuse) to depressive symptoms.
The sample size was a little small so that the inference were drawn prudently. Except gene data, other were collected by self-reported questionnaire instruments which inevitably brought recall bias.
PRS and CT could have adverse impact on depressive symptoms, resilience could alleviate these risk effects as a moderator and a mediator. The findings have important implications for prevention and intervention in adolescent depressive symptoms.
多基因风险评分（PRS）是一种揭示多个基因效应的方法。关于 PRS 与儿童期创伤（CT）和韧性对青少年抑郁症状的影响的研究较少，尤其是韧性在其中的功能机制。
本队列研究对 718 名 10-14 岁的中国青少年进行了调查，包括 CT、韧性、抑郁症状和表型数据。通过对抑郁症状的等位基因加权累积效应计算 PRS。通过中介和调节模型分析它们之间的关系。
PRS 和 CT 是抑郁症状的危险因素。PRs×CT 对抑郁症状的交互作用无统计学意义。韧性作为 CT（情感虐待、情感忽视、身体忽视）对抑郁症状的保护中介，以及 CT（情感虐待）对抑郁症状的调节因素。
样本量有点小，因此推断要谨慎。除基因数据外，其他数据均通过自我报告的问卷工具收集，这不可避免地带来了回忆偏差。
PRS 和 CT 可能对抑郁症状产生不良影响，韧性可以作为一个调节因素和中介因素来减轻这些风险效应。这些发现对青少年抑郁症状的预防和干预具有重要意义。
