Division of Facial Plastic Reconstructive, Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia.
Division of Larynx Pharynx, Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia.
Facial Plast Surg. 2021 Jun;37(3):325-332. doi: 10.1055/s-0040-1717083. Epub 2021 Jan 14.
Autologous growth factor (AGF) is a cytokine that has gained medical research interest because it helps improve and accelerate the wound healing process. Platelet-rich fibrin (PRF) is the latest generation of platelet concentrate that can be obtained through a simple procedure known as AGF referencing. One of the most common complications of total laryngectomy (TL) is pharyngocutaneous fistula. To prevent this complication, health care providers must closely monitor the postoperative wound healing process.This study aimed to investigate the effectiveness of PRF application in enhancing wound healing after TL. A randomized controlled trial was conducted in the Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital Universitas Indonesia, Jakarta, Indonesia, from June 2019 to December 2019. We included 20 patients who underwent TL for laryngeal squamous cell carcinoma. They were divided into two groups (10 patients who received applied autologous PRF around the esophageal stoma during TL and another 10 patients as the control). These patients were observed for 2 weeks postoperatively. In the bivariate analysis performed using the chi-square test, the pain threshold and edema of postoperative wounds in the PRF-treated group demonstrated significant differences compared with those in the control group. PRF application in TL enhanced the postoperative wound healing process, especially with regard to edema and pain.
自体生长因子（AGF）是一种细胞因子，它因其有助于改善和加速伤口愈合过程而引起医学研究的兴趣。富含血小板纤维蛋白（PRF）是血小板浓缩物的最新一代，可以通过一种称为 AGF 参考的简单程序获得。全喉切除术（TL）最常见的并发症之一是咽皮瘘。为了预防这种并发症，医护人员必须密切监测术后伤口愈合过程。本研究旨在探讨 PRF 应用在增强 TL 后伤口愈合方面的有效性。在印度尼西亚雅加达的 Cipto Mangunkusumo 医院医学系耳鼻喉科-头颈外科进行了一项随机对照试验，时间为 2019 年 6 月至 2019 年 12 月。我们纳入了 20 名因喉鳞状细胞癌而接受 TL 的患者。他们被分为两组（10 名在 TL 期间在食管造口周围应用自体 PRF 的患者和另 10 名作为对照组的患者）。这些患者在术后 2 周内进行观察。在使用卡方检验进行的双变量分析中，PRF 治疗组的术后伤口疼痛阈值和水肿与对照组相比有显著差异。PRF 在 TL 中的应用增强了术后伤口愈合过程，特别是在水肿和疼痛方面。
