Department of Clinical Nutrition and Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Nutrition and Metabolic Diseases Research Center and Department of Nutrition, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Int J Clin Pract. 2021 May;75(5):e14022. doi: 10.1111/ijcp.14022. Epub 2021 Feb 2.
The pathogenesis of type 2 diabetes mellitus (T2DM) is associated with chronic oxidative stress and inflammation. It is well known that the expression of some miRNAs such as miRNA-146a is upregulated in diabetic and hyperglycaemic patients, whereas circulating miRNA-126 is reduced. Therefore, we aimed to determine the effects of astaxanthin (AST) supplementation on the circulating malondialdehyde (MDA) and interleukin 6 (IL-6) levels, and the expression of miR-146a and miR-126 in patients with T2DM.
This randomised, double-blind, placebo-controlled clinical trial was conducted in 44 patients with T2DM randomly receiving 8 mg/d of oral AST (n = 22) or placebo (n = 22) for 8 weeks.
We observed that AST supplementation could decrease plasma levels of MDA and IL-6 (P < .05) and decrease the expression level of miR-146a over time (fold change: -1/388) (P < .05).
AST supplementation might be beneficial for improving circulating MDA and IL-6 and the down-regulation of miR-146a. However, future investigations are suggested to confirm these results.
2 型糖尿病（T2DM）的发病机制与慢性氧化应激和炎症有关。众所周知，一些 miRNA 的表达如 miRNA-146a 在糖尿病和高血糖患者中上调，而循环 miRNA-126 则减少。因此，我们旨在确定虾青素（AST）补充对 T2DM 患者循环丙二醛（MDA）和白细胞介素 6（IL-6）水平以及 miR-146a 和 miR-126 表达的影响。
这项随机、双盲、安慰剂对照的临床试验在 44 名 T2DM 患者中进行，他们随机接受 8mg/d 的口服 AST（n=22）或安慰剂（n=22）治疗 8 周。
我们观察到 AST 补充可以降低血浆 MDA 和 IL-6 水平（P<.05），并随着时间的推移降低 miR-146a 的表达水平（倍数变化：-1/388）（P<.05）。
AST 补充可能有益于改善循环 MDA 和 IL-6 以及下调 miR-146a。然而，建议进行进一步的研究来证实这些结果。
