Awino Joseph K, Zhao Yan
Department of Chemistry, Iowa State University, Ames, Iowa 50011-3111, United States.
ACS Biomater Sci Eng. 2015 Jun 8;1(6):425-430. doi: 10.1021/acsbiomaterials.5b00042. Epub 2015 May 27.
The wide usage and subsequent leakage of nonsteroidal anti-inflammatory drugs (NSAIDs) into the environment present an urgent need to create materials for selective binding of NSAID drugs, which are highly similar to one another in structure and functionality. Surface-core double-cross-linking of cationic micelles containing Naproxen or Indomethacin as the template yielded molecularly imprinted nanoparticles (MINPs) for these drugs. The nanoparticle receptors resembled water-soluble proteins in their hydrophilic exterior and hydrophobic core with guest-tailored binding pockets. Their binding selectivity for their templates over other NSAID analogues rivaled that of antibodies prepared through much lengthier procedures.
非甾体抗炎药（NSAIDs）的广泛使用及其随后向环境中的泄漏，迫切需要制备能够选择性结合NSAID药物的材料，这些药物在结构和功能上彼此高度相似。以萘普生或吲哚美辛为模板的阳离子胶束进行表面-核双交联，得到了这些药物的分子印迹纳米颗粒（MINPs）。纳米颗粒受体在其亲水的外部和疏水的核心具有与客体匹配的结合口袋，类似于水溶性蛋白质。它们对模板的结合选择性优于其他NSAID类似物，可与通过更冗长程序制备的抗体相媲美。
