Chen Ke, Qiu Nianxiang, Deng Qihuang, Kang Min-Ho, Yang Hui, Baek Jae-Uk, Koh Young-Hag, Du Shiyu, Huang Qing, Kim Hyoun-Ee
Department of Materials Science and Engineering, Seoul National University, Seoul 151-744, Republic of Korea.
Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.
ACS Biomater Sci Eng. 2017 Oct 9;3(10):2293-2301. doi: 10.1021/acsbiomaterials.7b00432. Epub 2017 Aug 29.
Herein, the cytocompatibility of selected MAX phases, TiAlC, TiSiC, and TiAlN, were systematically evaluated using tests for the first time. These phases were anoxic to preosteoblasts and fibroblasts. Compared with the strong viable fibroblasts, the different cellular responses of these materials were clearly distinguishable for the preosteoblasts. Under an osteoblastic environment, TiAlN exhibited better cell proliferation and differentiation performance than TiAlC and TiSiC. Moreover, the performance was superior to that of a commercial Ti-6Al-4V alloy and comparable to that of pure Ti. A possible mechanism was suggested based on the different surface oxidation products, which were determined from the binding energy of adsorbed Ca ions using first-principles calculations. Compared with the partially oxidized TiCO layer on TiAlC and TiSiC, the partially oxidized TiNO layer on the TiAlN had a stronger affinity to the Ca ions, which indicated the good cytocompatibility of TiAlN.
在此，首次使用测试系统地评估了选定的MAX相TiAlC、TiSiC和TiAlN的细胞相容性。这些相对于前成骨细胞和成纤维细胞是缺氧的。与活力较强的成纤维细胞相比，这些材料对前成骨细胞的不同细胞反应明显可辨。在成骨细胞环境下，TiAlN表现出比TiAlC和TiSiC更好的细胞增殖和分化性能。此外，其性能优于商用Ti-6Al-4V合金，与纯Ti相当。基于不同的表面氧化产物提出了一种可能的机制，这些产物是通过第一性原理计算从吸附Ca离子的结合能确定的。与TiAlC和TiSiC上的部分氧化TiCO层相比，TiAlN上的部分氧化TiNO层对Ca离子具有更强的亲和力，这表明TiAlN具有良好的细胞相容性。
