Wang Kewei, Chen Qianqian, Xue Wei, Li Sha, Liu Zonghua
Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, No. 601 West Huangpu Road, Guangzhou 510632, China.
ACS Biomater Sci Eng. 2017 Oct 9;3(10):2325-2335. doi: 10.1021/acsbiomaterials.7b00499. Epub 2017 Sep 26.
In the treatment of cancers, molybdenum disulfide (MoS) has shown great potential as a photoabsorbing agent in photothermal therapy and also as an antitumor drug delivery system in chemotherapy. However, the poor dispersibility and stability of MoS in aqueous solutions limit its applications in cancer therapy. To overcome the shortcomings, MoS was modified mainly by surface adsorption of linear polymers, such as chitosan and poly(ethylene glycol). As reported, the linear polymers could be more rapidly cleared from blood circulation than their branched counterparts. Herein, we developed hyperbranched polyglycidyl (HPG)-modified MoS (MoS-HPG) by absorbing HPG on the MoS surface. The MoS-HPG as a novel photoabsorbing agent was also used as a nanoscaled carrier to load antitumor drug doxorubicin hydrochloride (DOX) (MoS-HPG-DOX) for combined chemo-photothermal therapy. The physicochemical and photothermal properties of MoS-HPG were measured, and the results indicate that MoS-HPG had good dispersion and stability in aqueous solutions and also high photothermal conversion efficiency. MoS-HPG displayed good biocompatibility in hemocompatibility and cytotoxicity evaluations in vitro. Furthermore, the combined chemo-photothermal therapy using MoS-HPG-DOX demonstrated better anticancer effect than the individual chemotherapy or photothermal therapy alone. From the results, MoS-HPG with combined chemo-photothermal therapy could be developed as a promising therapeutic formulation for clinical cancer treatment.
在癌症治疗中，二硫化钼（MoS）在光热疗法中作为光吸收剂以及在化疗中作为抗肿瘤药物递送系统都显示出了巨大潜力。然而，MoS在水溶液中的分散性和稳定性较差，限制了其在癌症治疗中的应用。为克服这些缺点，主要通过壳聚糖和聚乙二醇等线性聚合物的表面吸附对MoS进行改性。据报道，线性聚合物比其支化对应物能更快地从血液循环中清除。在此，我们通过在MoS表面吸附超支化聚缩水甘油（HPG）来制备HPG改性的MoS（MoS-HPG）。MoS-HPG作为一种新型光吸收剂，还用作纳米级载体来负载抗肿瘤药物盐酸阿霉素（DOX）（MoS-HPG-DOX）用于联合化疗-光热疗法。对MoS-HPG的物理化学和光热性质进行了测定，结果表明MoS-HPG在水溶液中具有良好的分散性和稳定性，并且光热转换效率高。在体外血液相容性和细胞毒性评估中，MoS-HPG显示出良好的生物相容性。此外，使用MoS-HPG-DOX的联合化疗-光热疗法显示出比单独的化疗或光热疗法更好的抗癌效果。从结果来看，具有联合化疗-光热疗法的MoS-HPG有望开发成为一种用于临床癌症治疗的有前景的治疗制剂。
