Silva Janine S F, Silva José Y R, de Sá Gilberto F, Araújo Silvany S, Filho Manoel A Gomes, Ronconi Célia M, Santos Thiago C, Júnior Severino A
Fundamental Department of Chemistry and Materials Science Program, Federal University of Pernambuco, 50670-901 Recife, Pernambuco, Brazil.
Department of Sciences Biological, Federal Rural University of Pernambuco, 52171-900 Recife, Pernambuco, Brazil.
ACS Omega. 2018 Sep 30;3(9):12147-12157. doi: 10.1021/acsomega.8b01067. Epub 2018 Sep 27.
Polyaniline-decorated ZIF-8 nanoparticles (nPANI@nZIF-8) were easily synthesized and employed as a multifunctional system for the delivery of the antitumor drug 5-fluorouracil (5-FU). Because of the storage ability of the network ZIF-8, 68% of the total amount of the 5-FU drug was released at pH 5.2. The system exhibits absorption in the near-infrared (NIR) region and can be used in the photothermal therapy owing to the presence of nPANI, which has a strong NIR uptake. This absorption causes local hyperthermia by aiding in the diffusion of the drug molecules contained by the polymer into nPANI@nZIF-8/5-FU achieving a greater release of the 5-FU drug, about 80% activated by an NIR laser (λ = 980 nm). This hyperthermia reached about 70 °C (200 μL, 1 mg mL nPANI@nZIF-8), which was directly proportional to the concentration of the material. Therefore, our work can aid in the construction of new chemo-photothermal platforms that may be employed in cancer therapy.
聚苯胺修饰的ZIF-8纳米颗粒（nPANI@nZIF-8）易于合成，并用作递送抗肿瘤药物5-氟尿嘧啶（5-FU）的多功能系统。由于网络状ZIF-8的储存能力，5-FU药物总量的68%在pH 5.2时释放。该系统在近红外（NIR）区域有吸收，并且由于存在具有强近红外吸收能力的nPANI，可用于光热疗法。这种吸收通过帮助聚合物中所含药物分子扩散到nPANI@nZIF-8/5-FU中引起局部热疗，实现5-FU药物的更大释放，约80%由近红外激光（λ = 980 nm）激活。这种热疗达到约70°C（200μL，1mg/mL nPANI@nZIF-8），与材料浓度成正比。因此，我们的工作有助于构建可用于癌症治疗的新型化学-光热平台。
