Xu L, Liu Y, Lai X F, Bai Y, Feng J N, Zhan S Y, Huang X J, Wang S F, Lu J
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
Peking University Institute of Hematology, Peking University People's Hospital, National Clinical Research, Center for Hematologic Disease, Beijing 100044, China.
Zhonghua Xue Ye Xue Za Zhi. 2020 Dec 14;41(12):984-988. doi: 10.3760/cma.j.issn.0253-2727.2020.12.003.
To analyze the epidemiological features of patients with plasma cell leukemia (PCL) and calculate the prevalence of PCL in urban China in 2016. Calculation in this study was based on China's urban basic medical insurance from 23 provinces between January 1, 2016 and December 31, 2016. The identification of the patients with PCL was based on the disease names and codes in the claim data. Subgroup analyses were carried out by sex, region, and age. To test the robustness of the results, we performed sensitivity analyses. Age-adjusted prevalence was calculated, based on the 2010 Chinese census data. The prevalence of PCL in urban China in 2016 was 0.11 per 100 000 population (95% 0.05-0.19) , and the male prevalence and female prevalence were 0.12 per 100 000 population (95% 0.06-0.21) and 0.10 per 100 000 population (95% 0.04-0.19) , respectively. The prevalence of PCL peaked at 70-79 years old. Sensitivity analyses proved the robustness of the primary result. The age-adjusted prevalence based on 2010 Chinese census data was 0.12 per 100 000 population (95% 0.11-0.13) . This study firstly analyzed the epidemiological characteristics of PCL in China, which can provide evidence for the research and policies regarding PCL.
分析浆细胞白血病（PCL）患者的流行病学特征，并计算2016年中国城市地区PCL的患病率。本研究的计算基于2016年1月1日至2016年12月31日期间23个省份的中国城市基本医疗保险数据。PCL患者的识别基于理赔数据中的疾病名称和编码。按性别、地区和年龄进行亚组分析。为检验结果的稳健性，我们进行了敏感性分析。根据2010年中国人口普查数据计算年龄调整患病率。2016年中国城市地区PCL的患病率为每10万人口0.11（95%可信区间0.05 - 0.19），男性患病率和女性患病率分别为每10万人口0.12（95%可信区间0.06 - 0.21）和每10万人口0.10（95%可信区间0.04 - 0.19）。PCL患病率在70 - 79岁达到峰值。敏感性分析证明了主要结果的稳健性。基于2010年中国人口普查数据的年龄调整患病率为每10万人口0.12（95%可信区间0.11 - 0.13）。本研究首次分析了中国PCL的流行病学特征，可为PCL的研究和政策提供依据。
