Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou, China.
Nat Prod Res. 2022 Mar;36(5):1245-1252. doi: 10.1080/14786419.2021.1872569. Epub 2021 Jan 15.
To search for antifungal leads, the metabolites of an insect-derived fungus ZMT01 were investigated, providing five sesquiterpenes (), including new molecules microsphaeropsisins D and E ( and ). The evaluated antifungal activities which are higher than the positive control triadimefon include: and towards (MICs 50, 25 mg L; triadimefon 100 mg L); , , and towards (MICs 25, 12.5, 25, 25; triadimefon 50 mg L), , and towards (MICs 25, 12.5, 25; triadimefon 80 mg L), and towards (MICs 100, 100; triadimefon 150 mg L). The bioassay displayed that the banana anthracnose control effect of (100 mg L) was also higher than that of triadimefon (Inhibition ratios 27.5 ± 2.5%, 55.3 ± 1.4%, 52.1 ± 1.3% for , 22.5 ± 2.1%, 47.2 ± 2.0%, 36.6 ± 2.2% for triadimefon at 4 d, 8 d and 12 d, respectively).[Formula: see text].
为了寻找抗真菌先导化合物，我们对一种昆虫来源的真菌 ZMT01 的代谢产物进行了研究，提供了五个倍半萜类化合物（），包括新分子微球藻素 D 和 E（和）。评估的抗真菌活性高于阳性对照三唑酮，包括：和对（MICs 50、25 mg/L；三唑酮 100 mg/L）；、、和对（MICs 25、12.5、25、25；三唑酮 50 mg/L），、、和对（MICs 25、12.5、25；三唑酮 80 mg/L），和对（MICs 100、100；三唑酮 150 mg/L）。生物测定显示，化合物（100 mg/L）对香蕉炭疽病的防治效果也高于三唑酮（4 d、8 d 和 12 d 时的抑制率分别为 27.5±2.5%、55.3±1.4%、52.1±1.3%，22.5±2.1%、47.2±2.0%、36.6±2.2%）。[公式：见正文]。
