College of Materials and Energy , South China Agricultural University , Guangzhou 510642 , China.
Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital , Guangzhou Medical University , Guangzhou 511436 , China.
J Agric Food Chem. 2019 Sep 25;67(38):10646-10652. doi: 10.1021/acs.jafc.9b04053. Epub 2019 Sep 13.
A new monosesquiterpene diacetylgliocladic acid (), a new dimeric sesquiterpene divirensol H (), and two exceptionally novel trimeric sesquiterpene trivirensols A and B ( and ), together with another eight known congeners, were purified from an endophytic fungus FY06, derived from Sonn. whose fruit is a delicious and popular food. All of them were identified by comprehensive spectroscopic analysis, combined with biosynthetic considerations. Trivirensols A and B are unprecedented trimers of which three subunits are connected by two ester bonds of the sesquiterpene class. Relative to the positive control triadimefon, all the tested metabolites showed strong inhibitory activities against at least one phytopathogenic fungus among , , , , and . Notably, as metabolites of the endophytic fungus from , they all presented strong antifungal activities against which causes anthracnose in .
从榕属植物果实中内生真菌 FY06 中分离得到 1 个新的单倍半萜二乙酰基降二叶古伦酸（）、1 个新的二聚倍半萜二呋甾醇 H（）以及 2 个新颖的三呋甾醇 A 和 B（和），连同另外 8 个已知同系物。通过全面的光谱分析，结合生物合成考虑，对所有化合物进行了鉴定。呋甾醇 A 和 B 是前所未有的三呋甾醇，其三个亚单位通过倍半萜类的两个酯键连接。与阳性对照三唑酮相比，所有测试的代谢物对至少一种植物病原菌（、、、、和）均表现出较强的抑制活性。值得注意的是，作为榕属内生真菌的代谢产物，它们均对引起炭疽病的炭疽病菌表现出较强的抗真菌活性。
