在中国浙江省，肌肉减少症与非酒精性脂肪肝的存在有关：一项横断面观察性研究。
Sarcopenia is associated with the presence of nonalcoholic fatty liver disease in Zhejiang Province, China: a cross-sectional observational study.
机构信息
Department of Geriatrics, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.
Zhejiang Provincial Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.
出版信息
BMC Geriatr. 2021 Jan 14;21(1):55. doi: 10.1186/s12877-020-01910-3.
BACKGROUND
Currently, both non-alcoholic fatty liver disease (NAFLD) and sarcopenia have attracted extensive attention in public health. However, the relationship between NAFLD and sarcopenia remains unclear. This study aimed to clarify the sex-specific association between sarcopenia and NAFLD according to the Asian Working Group for Sarcopenia (AWGS).
METHODS
Dual-energy X-ray absorptiometry (DXA) and hepatic ultrasonography were measured in 578 participants (92 men and 486 women) during their annual health examinations. Multivariate logistic regression models were used to explore the association between NAFLD and sarcopenia with its two components.
RESULTS
A total of 154 participants (30 men and 124 women) had NAFLD. The prevalence of sarcopenia was higher among the participants with NAFLD than among those without NAFLD (men: 20.0% vs. 9.7%, P = 0.295, women: 15.3% vs. 8.0%, P = 0.019). Low muscle mass (LMM) was independently associated with NAFLD in both men and women (men: odds ratio [OR], 2.88; 95% confidence interval [CI] 1.52-5.46; women: OR, 2.08; 95% CI 1.63-2.67). However, low muscle strength (LMS) was independently associated with NAFLD only in male participants, with an OR of 1.15 (95% CI 1.02-1.28).
CONCLUSION
The occurrence of sarcopenia was associated with a higher risk of NAFLD, especially in men, as demonstrated by lower muscle mass and lower muscle strength.
背景
目前，非酒精性脂肪性肝病（NAFLD）和肌少症均受到公众健康的广泛关注。然而，NAFLD 和肌少症之间的关系尚不清楚。本研究旨在根据亚洲肌少症工作组（AWGS）阐明肌少症与 NAFLD 之间的性别特异性关联。
方法
在年度健康检查中，使用双能 X 射线吸收法（DXA）和肝脏超声测量了 578 名参与者（92 名男性和 486 名女性）的数据。使用多变量逻辑回归模型探讨了 NAFLD 与肌少症及其两个组成部分之间的关系。
结果
共有 154 名参与者（30 名男性和 124 名女性）患有 NAFLD。患有 NAFLD 的参与者中肌少症的患病率高于未患有 NAFLD 的参与者（男性：20.0%比 9.7%，P=0.295，女性：15.3%比 8.0%，P=0.019）。低肌肉量（LMM）与男性和女性的 NAFLD 均独立相关（男性：比值比[OR]，2.88；95%置信区间[CI]，1.52-5.46；女性：OR，2.08；95%CI，1.63-2.67）。然而，低肌肉力量（LMS）仅与男性参与者的 NAFLD 独立相关，其 OR 为 1.15（95%CI，1.02-1.28）。
结论
肌少症的发生与 NAFLD 的风险增加相关，尤其是在男性中，表现为肌肉量和肌肉力量降低。
Zotero 插件