Department of Psychiatry, Bellvitge University Hospital. Bellvitge Biomedical Research Institute (IDIBELL), Neurosciences Group - Psychiatry and Mental Health, Feixa Llarga s/n. 08907, L'Hospitalet de Llobregat, Barcelona, Spain.
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carlos III Health Institute, Madrid, Spain.
BMC Psychiatry. 2021 Jan 14;21(1):42. doi: 10.1186/s12888-021-03038-z.
Sleep disturbances have been reported in obsessive-compulsive disorder (OCD) patients, with heterogeneous results. The aim of our study was to assess sleep function in OCD and to investigate the relationship between sleep and the severity of obsessive-compulsive (OC) symptoms, depressive symptoms and trait anxiety.
Sleep quality was measured in 61 OCD patients and 100 healthy controls (HCs) using the Pittsburgh Sleep Quality Index (PSQI). Multiple linear regression was conducted to explore the association between sleep and psychopathological measures; a mediation analysis was also performed.
OCD patients showed poor sleep quality and more sleep disturbances compared to HCs. The severity of depression, trait anxiety and OC symptomatology were correlated with poor sleep quality. Multiple linear regression analyses controlling for potential confounders revealed that the severity of depression and trait anxiety were independently related to poor sleep quality in OCD. A mediation analysis showed that both the severity of trait anxiety and depression mediate the relationship between the severity of OC symptoms and poor sleep quality among patients with OCD.
Our findings support the existence of sleep disturbances in OCD. Trait anxiety and depression play a key role in sleep quality among OCD patients.
强迫症（OCD）患者存在睡眠障碍，但其结果存在差异。本研究旨在评估 OCD 患者的睡眠功能，并探讨睡眠与强迫症（OC）症状严重程度、抑郁症状和特质焦虑之间的关系。
采用匹兹堡睡眠质量指数（PSQI）对 61 例 OCD 患者和 100 例健康对照者（HCs）的睡眠质量进行评估。采用多元线性回归分析探讨睡眠与精神病理学指标之间的关系；并进行中介分析。
与 HCs 相比，OCD 患者的睡眠质量较差，睡眠障碍更多。抑郁严重程度、特质焦虑和 OC 症状严重程度与睡眠质量差相关。在控制潜在混杂因素的多元线性回归分析中，抑郁严重程度和特质焦虑严重程度与 OCD 患者的睡眠质量差独立相关。中介分析表明，特质焦虑和抑郁的严重程度均在 OCD 患者 OC 症状严重程度与睡眠质量差之间起中介作用。
本研究结果支持 OCD 患者存在睡眠障碍。特质焦虑和抑郁在 OCD 患者的睡眠质量中起关键作用。
