多囊卵巢综合征中的非编码 RNA：系统评价和荟萃分析。

Non-coding RNAs in polycystic ovary syndrome: a systematic review and meta-analysis.

机构信息

Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, People's Republic of China.

Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People's Republic of China.

出版信息

Reprod Biol Endocrinol. 2021 Jan 14;19(1):10. doi: 10.1186/s12958-020-00687-9.

DOI:10.1186/s12958-020-00687-9

PMID:33446212

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7807442/

Abstract

BACKGROUND

Genetic, environmental and epigenetical factors may play important roles in the pathogenesis of polycystic ovary syndrome (PCOS), however the etiology of PCOS remains unclear. Studies indicated that non-coding RNAs (ncRNAs) were involved in the occurrence and development of PCOS. Thus, we aim to perform a systematic review and meta-analysis to investigate the presence and dysregulated expression of ncRNAs in human PCOS.

METHODS

We searched in PubMed, Medline, Web of Science and Embase until July 2019 and summarized all eligible publications focusing on microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and small interfering RNAs (siRNAs) in PCOS.

RESULTS

Sixty-seven articles were included in our systematic review and 9 articles were included in meta-analysis. There is little overlap between studies when comparing miRNA profiles. Sensitivity analysis showed that the expression of miR-93 was upregulated in PCOS patients (WMD 0.75, P < 0.00001), without heterogeneity among remaining studies (I = 0%).

CONCLUSION

A large number of ncRNAs with altered levels were observed in plasma, serum, follicular fluid, granulosa cells or other issues from PCOS patients. Aberrant ncRNAs expression in PCOS may lead to aberrant steroidogenesis, adipocyte dysfunction, altered ovarian cell proliferation and/or apoptosis and have the potential to be used as diagnostic biomarkers.

摘要

背景

遗传、环境和表观遗传因素可能在多囊卵巢综合征（PCOS）的发病机制中起重要作用，但 PCOS 的病因仍不清楚。研究表明，非编码 RNA（ncRNAs）参与了 PCOS 的发生和发展。因此，我们旨在进行系统评价和荟萃分析，以研究 ncRNAs 在人 PCOS 中的存在和失调表达。

方法

我们在 PubMed、Medline、Web of Science 和 Embase 中进行了检索，截至 2019 年 7 月，总结了所有关注 PCOS 中 microRNAs（miRNAs）、长链非编码 RNA（lncRNAs）、环状 RNA（circRNAs）和小干扰 RNA（siRNAs）的合格出版物。