Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, 56000, Kuala Lumpur, Malaysia.
Dietetics Program, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, 50300, Kuala Lumpur, Malaysia.
Sci Rep. 2021 Jan 14;11(1):1416. doi: 10.1038/s41598-020-80812-1.
The metabolic impact of circulating fatty acids (FAs) in patients requiring hemodialysis (HD) is unknown. We investigated the associations between plasma triglyceride (TG) FAs and markers of inflammation, insulin resistance, nutritional status and body composition. Plasma TG-FAs were measured using gas chromatography in 341 patients on HD (age = 55.2 ± 14.0 years and 54.3% males). Cross-sectional associations of TG-FAs with 13 markers were examined using multivariate linear regression adjusted for potential confounders. Higher levels of TG saturated fatty acids were associated with greater body mass index (BMI, r = 0.230), waist circumference (r = 0.203), triceps skinfold (r = 0.197), fat tissue index (r = 0.150), serum insulin (r = 0.280), and homeostatic model assessment of insulin resistance (r = 0.276), but lower malnutrition inflammation score (MIS, r = - 0.160). Greater TG monounsaturated fatty acid levels were associated with lower lean tissue index (r = - 0.197) and serum albumin (r = - 0.188), but higher MIS (r = 0.176). Higher levels of TG n-3 polyunsaturated fatty acids (PUFAs) were associated with lower MIS (r = - 0.168) and interleukin-6 concentrations (r = - 0.115). Higher levels of TG n-6 PUFAs were associated with lower BMI (r = - 0.149) but greater serum albumin (r = 0.112). In conclusion, TG monounsaturated fatty acids were associated with poor nutritional status, while TG n-3 PUFAs were associated with good nutritional status. On the other hand, TG saturated fatty acids and TG n-6 PUFAs had both favorable and unfavorable associations with nutritional parameters.
在需要血液透析（HD）的患者中，循环脂肪酸（FA）的代谢影响尚不清楚。我们研究了血浆甘油三酯（TG）FA 与炎症标志物、胰岛素抵抗、营养状况和身体成分之间的关系。使用气相色谱法测量了 341 名 HD 患者（年龄=55.2±14.0 岁，54.3%为男性）的血浆 TG-FA。使用多元线性回归，在调整了潜在混杂因素后，检查了 TG-FA 与 13 个标志物的横断面关联。较高的 TG 饱和脂肪酸水平与较高的体重指数（BMI，r=0.230）、腰围（r=0.203）、肱三头肌皮褶厚度（r=0.197）、脂肪组织指数（r=0.150）、血清胰岛素（r=0.280）和稳态模型评估的胰岛素抵抗（r=0.276）相关，但与营养不良炎症评分（MIS，r=−0.160）较低相关。较高的 TG 单不饱和脂肪酸水平与较低的瘦组织指数（r=−0.197）和血清白蛋白（r=−0.188）相关，但与较高的 MIS（r=0.176）相关。较高的 TG n-3 多不饱和脂肪酸（PUFA）水平与较低的 MIS（r=−0.168）和白细胞介素-6 浓度（r=−0.115）相关。较高的 TG n-6 PUFA 水平与较低的 BMI（r=−0.149）但较高的血清白蛋白（r=0.112）相关。总之，TG 单不饱和脂肪酸与营养状况差有关，而 TG n-3 PUFA 与营养状况良好有关。另一方面，TG 饱和脂肪酸和 TG n-6 PUFA 与营养参数既有有利的关联，也有不利的关联。
