Mamo Ayele, Mama Mohammedaman, Solomon Damtew, Mohammed Mesud
Department of Pharmacy, School of Medicine, Madda Walabu University Goba Referral Hospital, Bale Goba, Ethiopia.
Department of Medical Laboratory Science, School of Medicine, Madda Walabu University Goba Referral Hospital, Bale Goba, Ethiopia.
Infect Drug Resist. 2021 Jan 5;13:4763-4771. doi: 10.2147/IDR.S285542. eCollection 2020.
Tuberculosis (TB) remains a main public health threat worldwide. Over 90% of tuberculosis cases occur in low- and middle-income countries that have fragile health infrastructures and constrained resources available. Ethiopia ranks third in Africa and eighth of 22 from TB burdened countries globally. Case detection as early as possible and ensuring a successful treatment rate should be the main focus points to decrease the burden of TB.
To evaluate tuberculosis treatment outcomes and predictors among tuberculosis treatment follow-up patients at Madda Walabu University Goba Referral Hospital.
Retrospective document review was conducted among TB patients in the tuberculosis clinic at Goba Referral Hospital from January 1, 2015 to December 30, 2019. Data were analyzed using SPSS version 25.0. Descriptive and logistic regressions analyses were performed to identify the rate and predictors of tuberculosis treatment outcomes. The odds ratio and 95% confidence interval were calculated to check the association between variables. ≤ 0.05 was considered statistically significant.
The mean age of participants was 33.8 ± 17.3 years, and more than half of them (58.4%, 218) were males. From the total 373 participants, 65 (17.4%) registered TB patients were diagnosed HIV-positive. The overall success rate was 320 (91.2%) with [95% CI, 88-94.3]. Among these, 91 (25.9%) were cured and 229 (65.2%) completed treatment whereas 8.8% with [95% CI, 5.7-12] were unsuccessful treatment outcomes. Among them, the majority 18 (5.1%) died, 6 (1.7%) were moved to MDR-TB center, 4 (1.1%) were lost to follow-up and 3 (0.9%) were documented as treatment failed.
The treatment failure rate was 8.8% with [95% CI, 5.7-12]. The proportion of TB patents who died was relatively higher. HIV-positive patients and old age people were predictors of unsuccessful treatment outcomes. Thus, the health facility should strengthen the evaluation of HIV-positive patients and old age patients to minimize mortality.
结核病仍然是全球主要的公共卫生威胁。超过90%的结核病病例发生在卫生基础设施薄弱且资源有限的低收入和中等收入国家。埃塞俄比亚在非洲排名第三，在全球22个结核病负担较重的国家中排名第八。尽早发现病例并确保成功治疗率应是减轻结核病负担的主要重点。
评估马达瓦拉布大学戈巴转诊医院结核病治疗随访患者的结核病治疗结果及预测因素。
对戈巴转诊医院结核病门诊2015年1月1日至2019年12月30日期间的结核病患者进行回顾性文件审查。使用SPSS 25.0版进行数据分析。进行描述性和逻辑回归分析以确定结核病治疗结果的发生率和预测因素。计算比值比和95%置信区间以检验变量之间的关联。P≤0.05被认为具有统计学意义。
参与者的平均年龄为33.8±17.3岁，其中超过一半（58.4%，218人）为男性。在总共373名参与者中，65名（17.4%）登记的结核病患者被诊断为HIV阳性。总体成功率为320例（91.2%），[95%置信区间，88 - 94.3]。其中，91例（25.9%）治愈，229例（65.2%）完成治疗，而8.8%[95%置信区间，5.7 - 12]治疗结果未成功。其中，大多数18例（5.1%）死亡，6例（1.7%）转至耐多药结核病中心，4例（1.1%）失访，3例（0.9%）记录为治疗失败。
治疗失败率为8.8%，[95%置信区间，5.7 - 12]。结核病患者死亡比例相对较高。HIV阳性患者和老年人是治疗结果未成功的预测因素。因此医疗机构应加强对HIV阳性患者和老年患者的评估以降低死亡率。
